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公开(公告)号:US20110052639A1
公开(公告)日:2011-03-03
申请号:US12837242
申请日:2010-07-15
申请人: Jens Holm , Mercedes Ferreras
发明人: Jens Holm , Mercedes Ferreras
CPC分类号: C07K14/415 , A61K38/00 , A61K2039/53
摘要: Novel recombinant allergens with multiple mutations and reduced IgE binding affinity are disclosed. The allergens are mutants of naturally occurring allergens. The overall α-carbon backbone tertiary structure is essentially preserved. Also disclosed is a method for preparing such recombinant allergens as well as uses thereof.
摘要翻译: 公开了具有多重突变和降低的IgE结合亲和力的新型重组变应原。 过敏原是天然存在的变应原的突变体。 总体上,α-碳骨架三级结构基本保持不变。 还公开了制备这种重组变应原及其应用的方法。