公开(公告)号：US08852657B2

公开(公告)日：2014-10-07

申请号：US11971523

申请日：2008-01-09

申请人： Ji-Fu Zhao ,  Julie Tseng-Crank ,  Mesfin Yimam ,  Qi Jia

发明人： Ji-Fu Zhao ,  Julie Tseng-Crank ,  Mesfin Yimam ,  Qi Jia

IPC分类号： A61K36/886 ,  A61K36/00 ,  A61K36/704 ,  A61K31/7048 ,  A61K31/35 ,  A61K31/352 ,  A61K36/48 ,  A61K36/38 ,  A61K36/489

CPC分类号： A61K31/352 ,  A61K31/35 ,  A61K31/7048 ,  A61K36/38 ,  A61K36/48 ,  A61K36/489 ,  A61K36/704 ,  A61K36/886

摘要： The identification and isolation of chromones and novel chromone compositions from plant sources that exhibit up-regulation of adiponectin production by adipocytes and the normalization of virtually hundreds of genes related to glucose and fatty acid metabolic and signaling pathways. The chromone compositions are effective in enhancing adiponectin production by adipocytes and regulating genes involved in fatty acid biosynthesis, mitochondrial β-oxidation of fatty acids, steroid biosynthesis, gluconeogenesis, fat transport, PPARα/RXRα liver signaling and xenobiotic metabolism. The chromone compositions can be used to increase insulin sensitivity, improve glucose tolerance, lower triglyceride levels and balance glucose levels in mammals. Included are methods for the prevention and treatment of a variety of diseases and conditions including, but not limited to insulin resistance, glucose intolerance, hyperglycemia, metabolic syndromes, dyslipidemia, and hypertriglyceridemia.

摘要翻译： 鉴定和分离来自植物来源的色酮和新的色酮组合物，其表现出脂肪细胞脂联素产生的上调，以及与葡萄糖和脂肪酸代谢和信号通路相关的几乎几百个基因的归一化。 色酮组合物可有效增强脂肪细胞的脂联素产生，调节脂肪酸生物合成，线粒体和脂肪酸的氧化，类固醇生物合成，糖异生，脂肪转运，PPARα/RXRα肝脏信号转导和异种生物代谢等因素的调控。 色酮组合物可用于增加胰岛素敏感性，改善葡萄糖耐量，降低甘油三酯水平和平衡哺乳动物中的葡萄糖水平。 包括预防和治疗各种疾病和病症的方法，包括但不限于胰岛素抵抗，葡萄糖不耐受，高血糖症，代谢综合征，血脂异常和高甘油三酯血症。

公开(公告)号：US20080166438A1

公开(公告)日：2008-07-10

申请号：US11971523

申请日：2008-01-09

申请人： Ji-Fu Zhao ,  Julie Tseng-Crank ,  Mesfin Yimam ,  Qi Jia

发明人： Ji-Fu Zhao ,  Julie Tseng-Crank ,  Mesfin Yimam ,  Qi Jia

IPC分类号： A61K31/352 ,  A61K31/7048 ,  A61P3/00 ,  A61K36/886

CPC分类号： A61K31/352 ,  A61K31/35 ,  A61K31/7048 ,  A61K36/38 ,  A61K36/48 ,  A61K36/489 ,  A61K36/704 ,  A61K36/886

摘要： The present invention describes the identification and isolation of chromones and novel chromone compositions from plant sources that exhibit up-regulation of adiponectin production by adipocytes and the normalization of virtually hundreds of genes related to glucose and fatty acid metabolic and signaling pathways. The chromone compositions are effective in enhancing adiponectin production by adipocytes and regulating genes involved in fatty acid biosynthesis, mitochondrial β-oxidation of fatty acids, steroid biosynthesis, gluconeogenesis, fat transport, PPARα/RXRα liver signaling and xenobiotic metabolism. The chromone compositions can be used to increase insulin sensitivity, improve glucose tolerance, lower triglyceride levels and balance glucose levels in mammals. Included in the present invention are methods for the prevention and treatment of a variety of diseases and conditions including, but not limited to insulin resistance, glucose intolerance, hyperglycemia, metabolic syndromes, dyslipidemia, and hypertriglyceridemia.

摘要翻译： 本发明描述了鉴定和分离来自植物来源的色酮和新的色酮组合物，其显示脂肪细胞脂联素产生的上调和几乎几百个与葡萄糖和脂肪酸代谢和信号通路相关基因的标准化。 色酮组合物有效促进脂肪细胞的脂联素产生，调节脂肪酸生物合成，脂肪酸线粒体β-氧化，类固醇生物合成，糖异生，脂肪转运，PPARalpha / RXRalpha肝信号转导和异种生物代谢的基因。 色酮组合物可用于增加胰岛素敏感性，改善葡萄糖耐量，降低甘油三酯水平和平衡哺乳动物中的葡萄糖水平。 本发明包括预防和治疗各种疾病和病症的方法，包括但不限于胰岛素抵抗，葡萄糖不耐受，高血糖症，代谢综合症，血脂异常和高甘油三酯血症。