公开(公告)号：US06358525B1

公开(公告)日：2002-03-19

申请号：US09343425

申请日：1999-06-30

申请人： Jian Hwa Guo ,  George William Skinner

发明人： Jian Hwa Guo ,  George William Skinner

IPC分类号： A61K920

CPC分类号： A61K9/205 ,  A61K9/2027 ,  A61K9/2054 ,  Y10S514/937 ,  Y10S514/944

摘要： A pharmaceutical composition has a blend of at least first and second components and a medicament in a sufficient amount to be therapeutic where the first component is hydroxypropylcellulose (HPC) and the second component is at least one other polymer selected from the group consisting of methylcellulose (MC), ethylhydroxyethylcellulose (EHEC), hydroxyethylmethylcellulose (HEMC), hydrophobically modified hydroxyethylcellulose (HMHEC), hydrophobically modified ethylhydroxyethylcellulose (HMEHEC), carboxymethylhydroxyethylcellulose (CMHEC), carboxymethyl hydrophobically modified hydroxyethylcellulose (CMHMHEC), guar, pectin, carrageenan, agar, algin, gellan gum, acacia, starch and modified starches, co-polymers of carboxyvinyl monomers, co-polymers of acrylate or methacrylate monomers, mono- and co-polymers of oxyethylene and oxypropylene and mixtures thereof and a medicament in a sufficient amount to be therapeutic, with the proviso that low-substituted hydroxypropylcellulose (L-HPC) is excluded from said first and second components. The medicament can be a variety of drugs or nutritional supplements. The pharmaceutical composition releases the medicament for a prolonged or sustained period of time and can be formulated into many dosage forms.

摘要翻译： 药物组合物具有至少第一组分和第二组分的混合物和足够量的药物，其中第一组分是羟丙基纤维素（HPC），第二组分是至少一种选自甲基纤维素（ 羟乙基纤维素（EHEC），羟乙基甲基纤维素（HEMC），疏水改性的羟乙基纤维素（HMHEC），疏水改性的乙基羟乙基纤维素（HMEHEC），羧甲基羟乙基纤维素（CMHEC），羧甲基疏水改性的羟乙基纤维素（CMHMHEC），瓜尔胶，果胶，角叉菜胶，琼脂， 结晶胶，阿拉伯树胶，淀粉和改性淀粉，羧乙烯基单体的共聚物，丙烯酸酯或甲基丙烯酸酯单体的共聚物，氧化乙烯和氧化丙烯的单聚合物和共聚物及其混合物，以及足够量的治疗剂， 条件是低取代的羟丙基纤维素（L-HPC）是 排除在所述第一和第二组分之外。 药物可以是各种药物或营养补充剂。 药物组合物释放药物持续长时间并且可以配制成许多剂型。