公开(公告)号：US07060272B2

公开(公告)日：2006-06-13

申请号：US10226318

申请日：2002-08-23

申请人： Jian Ni ,  Craig A Rosen ,  James G Pan ,  Reiner L Gentz ,  Vishva M Dixit

发明人： Jian Ni ,  Craig A Rosen ,  James G Pan ,  Reiner L Gentz ,  Vishva M Dixit

IPC分类号： A61K39/395 ,  A61K51/10 ,  C07K16/30

CPC分类号： C07K14/70578

摘要： The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity.

摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新的含有死亡域的受体-4（DR4）蛋白。 特别地，提供编码人DR4蛋白的分离的核酸分子。 还提供了DR4多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定DR4活性的激动剂和拮抗剂的筛选方法。