公开(公告)号：US20190091147A1

公开(公告)日：2019-03-28

申请号：US15751577

申请日：2017-04-27

申请人： Jiangnan University

发明人： Liping ZHANG ,  Ren LIU ,  Caihua NI ,  Yuanyuan Ding ,  Gang SHI ,  Xinxin Sang

IPC分类号： A61K9/107 ,  A61K47/34 ,  C08J3/07 ,  C08J3/24 ,  C08G73/02

摘要： Disclosed is a preparation method for charge reversal and reversibly crosslinked redox-sensitive nanomicelles, falling within the technical field of biomedical materials. The method comprises: synthesizing thiocinamide from lipoic acid and ethylenediamine under an N,N′-carbonyl diimidazole catalyst; and polymerizing thiocinamide, polyethylene glycol diglycidyl ether and lysine through a nucleophilic addition mechanism to prepare a poly(lysine-co-polyethylene glycol diglycidyl ether-co-thiocinamide) terpolymer. The micelle is endowed with excellent anti-protein nonspecific adsorption and enhanced cell uptake property through a self-assembly and protonation/deprotonation action; and a disulfide bond in lipoyl may form a linear polydisulfide structure under the action of 1,4-dithiothreitol, so that a micelle core is crosslinked, and a crosslinked structure is destroyed in the cell under a redox condition, and controlled release of a drug can be achieved. The Nanomicelle of the present invention is expected to be a carrier of drugs for treating cancers.