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    AMORPHOUS ROTIGOTINE TRANSDERMAL SYSTEM
    1.
    发明申请
    AMORPHOUS ROTIGOTINE TRANSDERMAL SYSTEM 审中-公开
    非晶转运系统

    公开(公告)号：US20100086582A1

    公开(公告)日：2010-04-08

    申请号：US12571509

    申请日：2009-10-01

    申请人： Jiansheng Tang ,  Joseph M. Deverich ,  Kenneth J. Miller, II ,  Russell D. Beste

    发明人： Jiansheng Tang ,  Joseph M. Deverich ,  Kenneth J. Miller, II ,  Russell D. Beste

    IPC分类号： A61K31/381 ,  A61K9/70 ,  A61P25/16

    CPC分类号： A61K9/7038 ,  A61K31/381

    摘要： The present invention refers to a transdermal delivery device comprising a backing layer, an adhesive matrix layer comprising a supersaturated concentration of rotigotine substantially in amorphous form within the adhesive matrix, and a release liner. The present invention also refers to a method of preparing an adhesive matrix containing a supersaturated amount of rotigotine substantially in amorphous form. Further, the present invention refers to a method of stabilizing and a method of reestablishing the meta-stable amorphous-drug transdermal system during its manufacturing, storing, shipping and handling process.

    摘要翻译： 本发明涉及一种透皮递送装置，其包括背层，粘合剂基质层，其包含在粘合剂基质内基本上无定形形式的过饱和浓度的罗替戈汀和释放衬垫。 本发明还涉及一种制备含有基本上无定形形式的过饱和量的罗替戈汀的粘合剂基质的方法。 此外，本发明涉及一种稳定化方法和在其制造，储存，运输和处理过程中重新建立间 - 稳定非晶药物透皮系统的方法。

    Amorphous drug transdermal systems, manufacturing methods, and stabilization
    2.
    发明申请
    Amorphous drug transdermal systems, manufacturing methods, and stabilization 审中-公开
    无定形药物透皮系统，制造方法和稳定性

    公开(公告)号：US20080226698A1

    公开(公告)日：2008-09-18

    申请号：US11725159

    申请日：2007-03-16

    申请人： Jiansheng Tang ,  Joseph M. Deverich ,  Kenneth J. Miller ,  Russell D. Beste

    发明人： Jiansheng Tang ,  Joseph M. Deverich ,  Kenneth J. Miller ,  Russell D. Beste

    IPC分类号： A61K31/215 ,  A61F13/02 ,  A61K31/4353 ,  A61K31/4355 ,  A61K9/70 ,  A61P43/00

    CPC分类号： A61K9/7053 ,  A61K9/7069

    摘要： The present invention refers to a transdermal delivery device comprising a backing layer, an adhesive matrix layer comprising a supersaturated concentration of an active agent substantially in amorphous form within the adhesive matrix, and a release liner. The present invention also refers to a method of preparing an adhesive matrix containing at least one supersaturated active agent substantially in amorphous form. Further, the present invention refers to a method to stabilize and a method to reestablish the meta-stable amorphous-drug transdermal system during its manufacturing, storing, shipping and handling process.

    摘要翻译： 本发明涉及一种透皮递送装置，其包括背衬层，包含过饱和浓度的基本上为无定形形式的粘合剂基质中的活性剂的粘合剂基质层和释放衬垫。 本发明还涉及制备含有至少一种基本上为无定形形式的过饱和活性剂的粘合剂基质的方法。 此外，本发明涉及一种稳定化方法以及在其制造，储存，运输和处理过程中重新建立间 - 稳定非晶药物透皮系统的方法。