公开(公告)号：US20140294818A1

公开(公告)日：2014-10-02

申请号：US14349550

申请日：2012-10-11

申请人： Jing Chen ,  Taro Hitosugi ,  Sumin Kang

发明人： Jing Chen ,  Taro Hitosugi ,  Sumin Kang

IPC分类号： C07C311/29 ,  A61K45/06 ,  C07K16/40 ,  A61K31/18

CPC分类号： C07C311/29 ,  A61K31/18 ,  A61K45/06 ,  C07C2603/24 ,  C07K16/40 ,  C07K2317/34 ,  C09B1/06 ,  C09B1/12

摘要： In certain embodiments, the disclosure relates to methods of treating or preventing a PGAM1 mediated condition such as cancer or tumor growth comprising administering an effective amount of PGAM1 inhibitor, for example, an anthracene-9,10-dione derivative to a subject in need thereof. In certain embodiments, the disclosure relates to methods of treating or preventing cancer, such as lung cancer, head and neck cancer, and leukemia, comprising administering a therapeutically effective amount of a pharmaceutical composition comprising a compound disclosed herein or pharmaceutically acceptable salt to a subject in need thereof.

摘要翻译： 在某些实施方案中，本公开涉及治疗或预防PGAM1介导的病症如癌症或肿瘤生长的方法，包括向有需要的受试者施用有效量的PGAM1抑制剂，例如蒽-9,10-二酮衍生物 。 在某些实施方案中，本公开涉及治疗或预防癌症的方法，例如肺癌，头颈癌和白血病，包括向受试者施用治疗有效量的包含本文公开的化合物或药学上可接受的盐的药物组合物 需要它。