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公开(公告)号:US06825208B2
公开(公告)日:2004-11-30
申请号:US10223860
申请日:2002-08-20
申请人: Jinglan Zhou , Leslie Robinson , Nikolaus M. Gubernator , Eddine Saiah , Xu Bai , Xin Gu
发明人: Jinglan Zhou , Leslie Robinson , Nikolaus M. Gubernator , Eddine Saiah , Xu Bai , Xin Gu
IPC分类号: A61K31473
CPC分类号: C07D221/18
摘要: This invention relates generally to tetracyclic tetrahydroquinoline compounds, and analogues thereof, and pharmaceutically acceptable salt forms thereof, which are selective inhibitors of serine protease enzymes, especially factor VIIa; pharmaceutical compositions containing the same; and methods of using the same as anticoagulant agents for modulation of the coagulation cascade.
摘要翻译: 本发明一般涉及四环四氢喹啉化合物及其类似物及其药学上可接受的盐形式,其是丝氨酸蛋白酶,特别是因子VIIa的选择性抑制剂; 含有该组合物的药物组合物; 以及使用其作为抗凝血剂调节凝血级联的方法。