公开(公告)号：US4888358A

公开(公告)日：1989-12-19

申请号：US236697

申请日：1988-08-25

申请人： Joan Huguet ,  Joseph M. Muchowski ,  Maria T. Lara

发明人： Joan Huguet ,  Joseph M. Muchowski ,  Maria T. Lara

IPC分类号： C07C405/00

CPC分类号： C07C405/00

摘要： Novel 13,14-dihydroprostaglandin derivatives of the formula ##STR1## wherein: m is 1 or 3;R.sub.1 is hydrogen or alkyl;R.sub.2 is hydrogen or lower alkyl;R.sub.3 and R.sub.4 are independently hydrogen or methyl;R.sub.5 is alkyl, CF.sub.3 (CH.sub.2).sub.n -- in which n is an integer of 3-5, cycloalkyl, or optionally substituted phenyl, benzyl or phenoxy; orR.sub.4 and R.sub.5 taken together with the carbon to which they are attached is cycloalkyl of 4-8 carbon atoms;X is cis --CH.dbd.CH-- or --CH.sub.2 CH.sub.2 -- when m is 3, orX is --CH.sub.2 CH.dbd.C.dbd.CH-- when m is 1;and the wavy lines represent the .alpha. or .beta. configuration with the proviso that when one wavy line is .alpha. the other is .beta.;or a pharmaceutically acceptable salt thereof,have been prepared. They are useful in particular for their antihypertensive and anti-ulcerogenic properties.

摘要翻译： 式（I）的新型13,14-二氢前列腺素衍生物，其中：m为1或3; R1是氢或烷基; R2是氢或低级烷基; R 3和R 4独立地是氢或甲基; R5是烷基，CF3（CH2）n-，其中n是3-5的整数，环烷基或任选取代的苯基，苄基或苯氧基; 或者R 4和R 5与它们所连接的碳一起是4-8个碳原子的环烷基; 当m为3时，X为顺式-CH = CH-或-CH2CH2-，当m为1时，X为-CH2CH = C = CH-; 而波浪线表示α或β构型，条件是当一条波浪线为α时，另一条波长为β; 或其药学上可接受的盐。 它们特别适用于其抗高血压和抗溃疡性质。