公开(公告)号：US20090104655A1

公开(公告)日：2009-04-23

申请号：US11920108

申请日：2006-04-26

申请人： Jochen Buchs ,  Doris Klee ,  Barbara Dittrich ,  Markus Jeude

发明人： Jochen Buchs ,  Doris Klee ,  Barbara Dittrich ,  Markus Jeude

IPC分类号： C12P1/00 ,  C12M1/22

CPC分类号： C12M23/34 ,  C12M29/04

摘要： In order to develop and optimize metering strategies for fed-batch fermentations in two or more reaction vessels, release systems containing nutrients are attached to the inner surfaces of the reaction vessels in areas that will come into contact with culture liquid placed in the vessels.

摘要翻译： 为了开发和优化两个或多个反应容器中补料分批发酵的计量策略，将含有营养物质的释放系统附着在反应容器的内表面，该区域将与放置在容器中的培养液接触。

公开(公告)号：US20070256510A1

公开(公告)日：2007-11-08

申请号：US11547021

申请日：2005-03-18

申请人： Jochen Buchs ,  Frank Kensy ,  Markus Samorski

发明人： Jochen Buchs ,  Frank Kensy ,  Markus Samorski

IPC分类号： G01N33/00 ,  B01L11/00

CPC分类号： G01N21/253 ,  G01N2035/00524 ,  G01N2201/08

摘要： The invention relates to a method and a device for the recording of process parameters of reaction fluids in several microreactors which are continuously agitated, at least until the termination of the reaction in all the microreactors. The process parameters in the microreactor are recorded during the reaction by means of at least one sensor optical system. According to the invention, the reliability of the method may be increased, whereby, during the recording of the value of a process parameter, for example, on recording an instantaneous value of the auto-fluorescence of the reaction fluids, the sensor optical system is held stationary. The relative movement of the agitated microreactor and each sensor optical system thus produced is not problematical when the electromagnetic radiation from each sensor optical system is introduced exclusively into one of the microreactors concerned during the recording of the process parameter in said microreactor and the radiation emitted from the reaction fluid is only incident on the sensor of the corresponding sensor optical system.

摘要翻译： 本发明涉及用于记录多个微反应器中反应流体的工艺参数的方法和装置，其连续搅拌，至少直到所有微反应器中的反应终止。 通过至少一个传感器光学系统在反应期间记录微反应器中的工艺参数。 根据本发明，可以提高该方法的可靠性，从而在记录工艺参数值时，例如在记录反应流体的自动荧光的瞬时值时，传感器光学系统是 保持静止。 当在所述微反应器中记录工艺参数期间将来自每个传感器光学系统的电磁辐射专门引入相关的微反应器之一时，由此产生的搅动的微反应器和每个传感器光学系统的相对运动并不成问题， 反应流体仅入射到相应的传感器光学系统的传感器上。