公开(公告)号：US20090253930A1

公开(公告)日：2009-10-08

申请号：US12084752

申请日：2006-11-09

申请人： John Colin Dunn ,  Dinesh Mistry ,  Martin Gower ,  Roger Pretot ,  Markus Schmid

发明人： John Colin Dunn ,  Dinesh Mistry ,  Martin Gower ,  Roger Pretot ,  Markus Schmid

IPC分类号： C07C229/00

CPC分类号： C07C213/06 ,  Y02P20/127 ,  C07C219/08

摘要： The invention relates to a process in which a compound R1COOR3 (I) is made by a transesterification reaction of an ester compound R1COOR2 (II) with an alcohol R3OH (III) in the presence of a transesterification catalyst, wherein R1 is H or C1-4 alkyl or CH2═CR4—; R2 is C1-4 alkyl; R3 is selected from the group consisting of alkyl having at least 4 carbon atoms, cycloalkyl having at least 5 carbon atoms, aryl, aralkyl, alkaryl and amino alkyl; and R4 is —H or —C1-4 alkyl, wherein alcohol R2OH (IV) is formed as a byproduct and in which said byproduct (IV) is removed by distillation in the presence of an entrainer, in which the entrainer is a compound that suppresses the formation of an azeotrope between compound (II) and byproduct (IV). The process can be useful in the preparation of esters such as dimethyl amino ethyl(meth)acrylate. The invention also provides a method of separating alcohols and esters. In a further form of the invention a process of preparing esters by a transesterification process is provided in which the transesterification catalyst is homogenous.

摘要翻译： 本发明涉及在酯交换催化剂存在下，通过酯化合物R1COOR2（II）与醇R3OH（Ⅲ）的酯交换反应制备化合物R1COOR3（Ⅰ）的方法，其中R1是H或C1- 4烷基或CH2-CR4-; R2是C1-4烷基; R 3选自具有至少4个碳原子的烷基，具有至少5个碳原子的环烷基，芳基，芳烷基，烷芳基和氨基烷基; R4是-H或-C1-4烷基，其中醇R2OH（Ⅳ）作为副产物形成，其中所述副产物（Ⅳ）在夹带剂存在下通过蒸馏除去，其中夹带剂是一种化合物， 抑制化合物（II）和副产物（IV）之间的共沸物的形成。 该方法可用于制备酯如二甲基氨基乙基（甲基）丙烯酸酯。 本发明还提供了分离醇和酯的方法。 在本发明的另一种形式中，提供了通过酯交换方法制备酯的方法，其中酯交换催化剂是均匀的。

公开(公告)号：US07999131B2

公开(公告)日：2011-08-16

申请号：US12084752

申请日：2006-11-09

申请人： John Colin Dunn ,  Dinesh Mistry ,  Martin Gower ,  Roger Prétôt ,  Markus Schmid

发明人： John Colin Dunn ,  Dinesh Mistry ,  Martin Gower ,  Roger Prétôt ,  Markus Schmid

IPC分类号： C07C67/02 ,  C07C69/66

CPC分类号： C07C213/06 ,  Y02P20/127 ,  C07C219/08

摘要： The invention relates to a process in which a compound R1COOR3 (I) is made by a transesterification reaction of an ester compound R1COOR2 (II) with an alcohol R3OH (III) in the presence of a transesterification catalyst, wherein R1 is H or C1-4 alkyl or CH2═CR4—; R2 is C1-4 alkyl; R3 is selected from the group consisting of alkyl having at least 4 carbon atoms, cycloalkyl having at least 5 carbon atoms, aryl, aralkyl, alkaryl and amino alkyl; and R4 is —H or —C1-4 alkyl, wherein alcohol R2OH (IV) is formed as a byproduct and in which said byproduct (IV) is removed by distillation in the presence of an entrainer, in which the entrainer is a compound that suppresses the formation of an azeotrope between compound (II) and byproduct (IV). The process can be useful in the preparation of esters such as dimethyl amino ethyl(meth)acrylate. The invention also provides a method of separating alcohols and esters. In a further form of the invention a process of preparing esters by a transesterification process is provided in which the transesterification catalyst is homogenous.

摘要翻译： 本发明涉及在酯交换催化剂存在下，通过酯化合物R1COOR2（II）与醇R3OH（Ⅲ）的酯交换反应制备化合物R1COOR3（Ⅰ）的方法，其中R1是H或C1- 4烷基或CH 2 = CR 4 - ; R2是C1-4烷基; R 3选自具有至少4个碳原子的烷基，具有至少5个碳原子的环烷基，芳基，芳烷基，烷芳基和氨基烷基; R4是-H或-C1-4烷基，其中醇R2OH（Ⅳ）作为副产物形成，其中所述副产物（Ⅳ）在夹带剂存在下通过蒸馏除去，其中夹带剂是一种化合物， 抑制化合物（II）和副产物（IV）之间的共沸物的形成。 该方法可用于制备酯如二甲基氨基乙基（甲基）丙烯酸酯。 本发明还提供了分离醇和酯的方法。 在本发明的另一种形式中，提供了通过酯交换方法制备酯的方法，其中酯交换催化剂是均匀的。

公开(公告)号：US08309755B2

公开(公告)日：2012-11-13

申请号：US13092784

申请日：2011-04-22

申请人： John Colin Dunn ,  Dinesh Mistry ,  Martin Gower ,  Roger Prétôt ,  Markus Schmid

发明人： John Colin Dunn ,  Dinesh Mistry ,  Martin Gower ,  Roger Prétôt ,  Markus Schmid

IPC分类号： C07C67/02

CPC分类号： C07C213/06 ,  Y02P20/127 ,  C07C219/08

摘要： The invention relates to a process in which a compound R1COOR3 (I) is made by a transesterification reaction of an ester compound R1COOR2 (II) with an alcohol R3OH (III) in the presence of a transesterification catalyst, wherein R1 is H or C1-4 alkyl or CH2═CR4—; R2 is C1-4 alkyl; R3 is selected from the group consisting of alkyl having at least 4 carbon atoms, cycloalkyl having at least 5 carbon atoms, aryl, aralkyl, alkaryl and amino alkyl; and R4 is —H or —C1-4 alkyl, wherein alcohol R2OH (IV) is formed as a byproduct and in which said byproduct (IV) is removed by distillation in the presence of an entrainer, in which the entrainer is a compound that suppresses the formation of an azeotrope between compound (II) and byproduct (IV). The process can be useful in the preparation of esters such as dimethyl amino ethyl (meth)acrylate. The invention also provides a method of separating alcohols and esters. In a further form of the invention a process of preparing esters by a transesterification process is provided in which the transesterification catalyst is homogenous.

摘要翻译： 本发明涉及在酯交换催化剂存在下，通过酯化合物R1COOR2（II）与醇R3OH（Ⅲ）的酯交换反应制备化合物R1COOR3（Ⅰ）的方法，其中R1是H或C1- 4烷基或CH 2 = CR 4 - ; R2是C1-4烷基; R 3选自具有至少4个碳原子的烷基，具有至少5个碳原子的环烷基，芳基，芳烷基，烷芳基和氨基烷基; R4是-H或-C1-4烷基，其中醇R2OH（Ⅳ）作为副产物形成，其中所述副产物（Ⅳ）在夹带剂存在下通过蒸馏除去，其中夹带剂是一种化合物， 抑制化合物（II）和副产物（IV）之间的共沸物的形成。 该方法可用于制备酯如二甲基氨基乙基（甲基）丙烯酸酯。 本发明还提供了分离醇和酯的方法。 在本发明的另一种形式中，提供了通过酯交换方法制备酯的方法，其中酯交换催化剂是均匀的。