公开(公告)号：US20150104442A1

公开(公告)日：2015-04-16

申请号：US14238253

申请日：2012-08-14

申请人： John Condeelis ,  Tony Tsz-Cheong Ng ,  Gregory Weitsman

发明人： John Condeelis ,  Tony Tsz-Cheong Ng ,  Gregory Weitsman

IPC分类号： G01N33/574

CPC分类号： G01N33/57415 ,  C07K16/2896 ,  G01N33/57496 ,  G01N2440/14 ,  G01N2800/56

摘要： Methods and products are provided for determining if a subject having a tumor is at risk of metastasis of the tumor. Specifically, the methods comprise detecting phosphorylated cofilin, and both phosphorylated and non-phosphorylated cofilin; quantifying the phosphorylated cofilin, and the total of phosphorylated and nonphosphorylated cofilin; and determining if a subject having the tumor is likely to experience metastasis of the tumor, based on the ratio of the amount of detected phosphorylated cofilin: total amount of phosphorylated and non-phosphorylated cofilin detected. Further disclosed are the types of tumor metastases that can be determined using the methods provided.

摘要翻译： 提供了用于确定具有肿瘤的受试者是否处于肿瘤转移风险的方法和产品。 具体地，所述方法包括检测磷酸化的椰子蛋白，以及磷酸化和非磷酸化的椰子蛋白; 定量磷酸化的cofilin，以及磷酸化和非磷酸化的cofilin的总和; 并且基于检测到的磷酸化的椰子蛋白的量：检测到的磷酸化和非磷酸化的椰子蛋白的总量，确定具有肿瘤的受试者是否可能经历肿瘤的转移。 进一步公开的是可以使用提供的方法确定的肿瘤转移的类型。