公开(公告)号：US20140024681A1

公开(公告)日：2014-01-23

申请号：US13980533

申请日：2012-01-20

申请人： John Francis Gilmer ,  Mark Ledwidge ,  Pat O'lynn ,  Shona Harmon ,  Mark Radomski ,  Carlos Medina Martin

发明人： John Francis Gilmer ,  Mark Ledwidge ,  Pat O'lynn ,  Shona Harmon ,  Mark Radomski ,  Carlos Medina Martin

IPC分类号： C07D493/04

CPC分类号： C07D493/04

摘要： A compound having the structural formula (I) and pharmaceutically acceptable salt and/or hydrates thereof, (I) wherein Y is an arylester or an C1-C8 alkylaryl ester, selected from the group consisting of: benzene, toluene, xylene, benzoic acid, benzoate, nicotinate, isonicotinate and halobenzene, which can be unsubstituted or substituted with at least one nitric oxide releasing group; and/or at least one of hydroxide, —Cl, —Br, a C1-C8 alkyl, benzyl, a C1-C8 alkoxy, benzyloxy, —NHC(O)R, —NH2, —NO2—ONO2, —(CH2)nONO2, —OC(O)[(CH2)n]cyclicONO2, —OCOArONO2, —OCOAr(CH2)nONO2 or a C1-C5 haloalkyl ester, wherein R is a C1-C8 alkyl or a C1-C8 alkoxy group, n=1-8 and m=3-10, to produce a super-aspirin effect.

摘要翻译： 具有结构式（I）的化合物及其药学上可接受的盐和/或其水合物，（I）其中Y是芳基酯或C1-C8烷基芳基酯，选自：苯，甲苯，二甲苯，苯甲酸 苯甲酸盐，烟酸盐，异烟酸盐和卤代苯，其可以是未取代的或被至少一个一氧化氮释放基团取代; 和/或氢氧化物，-Cl，-Br，C1-C8烷基，苄基，C1-C8烷氧基，苄氧基，-NHC（O）R，-NH2，-NO2-ONO2， - （CH2） NONO 2，-OC（O）[（CH 2）n]环氧基，-OCOOOR 2，-OCOAr（CH 2）nONO 2或C 1 -C 5卤代烷基酯，其中R是C 1 -C 8烷基或C 1 -C 8烷氧基，n = 1-8和m = 3-10，以产生超阿司匹林效应。