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公开(公告)号：US10401156B2
公开(公告)日：2019-09-03
申请号：US16110023
申请日：2018-08-23
摘要： A computer-implemented method for determining a quantification of the deformation of the sample is implemented using a computer device in communication with a memory. The method includes receiving, by the computer device, a first image of the sample and a second image of the sample. The method also includes registering the first image to the second image using a warping function. The warping function maps a plurality of pixels in the first image to a plurality of pixels in the second image. A first displacement field for the sample is determined based on the warping function, where the first displacement field includes at least a portion of the warping function. A first quantification of the deformation of the sample is determined based at least in part on the displacement field.
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2.发明申请公开(公告)号：US20190219382A1
公开(公告)日：2019-07-18
申请号：US16110023
申请日：2018-08-23
CPC分类号： G01B11/16 , G06T7/30 , G06T2207/10004 , G06T2207/30024 , G06T2207/30108
摘要： A computer-implemented method for determining a quantification of the deformation of the sample is implemented using a computer device in communication with a memory. The method includes receiving, by the computer device, a first image of the sample and a second image of the sample. The method also includes registering the first image to the second image using a warping function. The warping function maps a plurality of pixels in the first image to a plurality of pixels in the second image. A first displacement field for the sample is determined based on the warping function, where the first displacement field includes at least a portion of the warping function. A first quantification of the deformation of the sample is determined based at least in part on the displacement field.
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3.发明申请ALTERING PROTEIN CONCENTRATIONS IN CEREBROSPINAL FLUID AND/OR BRAIN INTERSTITIAL FLUID 审中-公开改变谷氨酸和/或脑间质流体中的蛋白质浓度公开(公告)号：US20140377319A1
公开(公告)日：2014-12-25
申请号：US14112817
申请日：2012-04-18
申请人： Eric C. Leuthardt , Daniel W. Moran , David Holtzman , Philip Bayly , David Brody , Ralph G. Dacey , Sam Fok , David Jeremiah Garrison , Guy M. Genin , Eriks Lusis , Rohit Pappu , Jingwei Xie , Greg Zipfel
发明人： Eric C. Leuthardt , Daniel W. Moran , David Holtzman , Philip Bayly , David Brody , Ralph G. Dacey , Sam Fok , David Jeremiah Garrison , Guy M. Genin , Eriks Lusis , Rohit Pappu , Jingwei Xie , Greg Zipfel
CPC分类号： A61K38/4886 , A61K9/0085 , A61K38/48 , A61K47/593 , C12N11/08 , C12Y304/24011
摘要： Devices and methods of altering protein concentrations in cerebrospinal fluid and/or brain interstitial fluid are disclosed. Devices include a support having at least one protease attached to the support. The device may further include a housing. Devices may be implantable for use in an in vivo active flow system or for use in an in vivo passive system. Devices may also be used in an ex vivo active flow system. Devices may also be used in a passive system to treat cerebrospinal fluid and/or brain interstitial fluid that is withdrawn, or in a passive system that is implanted surgically. Methods include contacting cerebrospinal fluid and/or brain interstitial fluid with a support including at least one protease attached to the support. Proteins contained in the cerebrospinal fluid and/or brain interstitial fluid are cleaved by the protease resulting in the reduction of protein in cerebrospinal fluid and/or brain interstitial fluid. Additionally, methods are disclosed for treating neurodegenerative diseases and neurological disorders.
摘要翻译： 公开了改变脑脊液和/或脑间质液中的蛋白质浓度的装置和方法。 装置包括具有至少一种蛋白酶附着到载体上的载体。 该装置还可以包括壳体。 装置可植入用于体内活动流系统或用于体内被动系统。 装置也可以用于离体活性流系统中。 装置还可以用于被动系统中以治疗被取出的脑脊液和/或脑组织液，或者在被手术植入的被动系统中。 方法包括使脑脊液和/或脑间质液与包含至少一种连接于载体的蛋白酶的载体接触。 包含在脑脊液和/或脑间质液中的蛋白质被蛋白酶切割，导致脑脊液和/或脑间质液中蛋白质的减少。 此外，公开了用于治疗神经变性疾病和神经障碍的方法。
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公开(公告)号：US20110251515A1
公开(公告)日：2011-10-13
申请号：US13083044
申请日：2011-04-08
申请人： Eric Claude Leuthardt , Benjamin E. Alexander , Samuel F. Wight , Jon T. Willie , David D. Limbrick , Guy M. Genin , Lihong Wang , Shelly Sakiyama-Elbert , David Allen Peters
发明人： Eric Claude Leuthardt , Benjamin E. Alexander , Samuel F. Wight , Jon T. Willie , David D. Limbrick , Guy M. Genin , Lihong Wang , Shelly Sakiyama-Elbert , David Allen Peters
IPC分类号： A61B5/00
CPC分类号： A61B5/031 , A61B5/6864 , A61B2560/063 , A61B2562/0247
摘要： Observing intracranial physiology includes inserting a bladder at least partially filled with a fluid into a subdural region of interest within a subject, wherein the bladder is coupled in flow communication with a means of indicating a pressure exerted on the bladder within the region of interest. Embodiments also include non-invasively interrogating the means of indicating to determine the pressure exerted on the bladder.
摘要翻译： 观察颅内生理学包括将至少部分地填充有流体的膀胱插入受试者内的感兴趣的硬膜下区域，其中膀胱与指示在感兴趣区域内施加在膀胱上的压力的方式流动连通。 实施例还包括非侵入性地询问指示确定施加在膀胱上的压力的装置。
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