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公开(公告)号:US5783179A
公开(公告)日:1998-07-21
申请号:US743613
申请日:1991-08-09
申请人: John J. Nestor, Jr. , Teresa H. Ho , Deborah A. Eppstein , Philip L. Felgner , Barbara P. Barna , Sharad D. Deodhar
发明人: John J. Nestor, Jr. , Teresa H. Ho , Deborah A. Eppstein , Philip L. Felgner , Barbara P. Barna , Sharad D. Deodhar
CPC分类号: C07K14/4737 , A61K38/00
摘要: Compounds having immunomodulatory activity comprising the optionally modified dodecapeptide fragment A-(SEQ ID No: 1)-B corresponding to residues 174 to 185 of C-reactive protein (CRP), pharmaceutical compositions thereof, and methods of treating cancer with the compositions. Liposomal formulations containing the CRP-peptide fragment are particularly efficacious when administered in conjunction with interleukin-2.
摘要翻译: 具有免疫调节活性的化合物包含对应于C-反应蛋白(CRP)的残基174至185的任选修饰的十二肽片段A-(SEQ ID No:1)-B,其药物组合物,以及用该组合物治疗癌症的方法。 含有CRP-肽片段的脂质体制剂与白介素-2联用时特别有效。