公开(公告)号：US07026446B1

公开(公告)日：2006-04-11

申请号：US09581924

申请日：1998-12-24

申请人： John Leslie Atwell ,  Peter Leonard Devine ,  Gregory Coia ,  Alexander Andrew Kortt ,  Gillian Wendy Perry ,  Peter Gregory Bundesen

发明人： John Leslie Atwell ,  Peter Leonard Devine ,  Gregory Coia ,  Alexander Andrew Kortt ,  Gillian Wendy Perry ,  Peter Gregory Bundesen

IPC分类号： C07K16/46 ,  C07K14/31 ,  C07K14/315 ,  C07K14/435 ,  C07K14/705

CPC分类号： C07K14/31 ,  C07K14/36 ,  C07K16/10 ,  C07K16/1081 ,  C07K16/18 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/622 ,  C07K2319/00

摘要： The invention relates to a chimeric antibody conjugate comprising an antigen binding region of a non-human antibody and an immunoglobulin constant region which comprises at least one CH domain or epitope thereof, with the proviso that the constant region is not a naturally occurring FC fragment. A bifunctional molecule for use in labelling an antibody derived from a first species, the bifunctional molecule comprising a binding region which binds to the antibody of the first species or to one or more groups provided thereon, and a constant region derived from an antibody of a second species, the constant region comprising at least one CH domain or an epitope thereof. The present invention relates to bifunctional molecules and complexes which are useful as positive control reagents in antibody based diagnostic tests. The present invention also relates to polynucleotides encoding these bifunctional molecules, and to diagnostic assays involving the use of these molecules.

摘要翻译： 本发明涉及包含非人抗体的抗原结合区和免疫球蛋白恒定区的嵌合抗体缀合物，其包含至少一个C H H结构域或其表位，条件是恒定区 不是天然存在的F C C片段。 用于标记来自第一物种的抗体的双功能分子，所述双功能分子包含与第一物种的抗体结合的结合区或其上提供的一个或多个基团的结合区和源自 第二种，恒定区包含至少一个C H H结构域或其表位。 本发明涉及在基于抗体的诊断测试中可用作阳性对照试剂的双功能分子和复合物。 本发明还涉及编码这些双功能分子的多核苷酸以及涉及使用这些分子的诊断测定。