公开(公告)号：US09289409B2

公开(公告)日：2016-03-22

申请号：US12413236

申请日：2009-03-27

申请人： John Myers Zanella ,  Vanja M King ,  Christopher M Hobot ,  S Mark Cox ,  Danielle Biggs ,  Katara Shaw ,  William F McKay ,  Kathy L Remsen

发明人： John Myers Zanella ,  Vanja M King ,  Christopher M Hobot ,  S Mark Cox ,  Danielle Biggs ,  Katara Shaw ,  William F McKay ,  Kathy L Remsen

IPC分类号： A01N43/00 ,  A61K31/33 ,  A61K31/255 ,  A61K9/00 ,  A61K9/20

CPC分类号： A61K31/255 ,  A61K9/0024 ,  A61K9/204

摘要： Effective treatments of pain and/or inflammation for extended periods of time are provided. Through the administration of an effective amount of sulindac or a pharmaceutically acceptable salt thereof at or near a target site, one can relieve pain and/or inflammation caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days, at least twenty-five days. In some embodiments, the relief can be for at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.

摘要翻译： 提供了长时间疼痛和/或炎症的有效治疗。 通过在目标部位处或附近施用有效量的舒林酸或其药学上可接受的盐，可以减轻由不同来源引起的疼痛和/或炎症，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位， 狭窄，恶性背痛和关节疼痛以及手术附带的疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天，至少二十五天。 在一些实施例中，浮雕可以是至少五十天，至少一百天，至少一百三十五天或至少一百八十天。

公开(公告)号：US09125917B2

公开(公告)日：2015-09-08

申请号：US12413197

申请日：2009-03-27

申请人： William F McKay ,  Christopher M Hobot ,  Danielle Biggs ,  Katara Shaw ,  John Myers Zanella ,  Vanja M King ,  Stephen Mark Cox ,  Kathy L Remsen

发明人： William F McKay ,  Christopher M Hobot ,  Danielle Biggs ,  Katara Shaw ,  John Myers Zanella ,  Vanja M King ,  Stephen Mark Cox ,  Kathy L Remsen

IPC分类号： A61F13/00 ,  A61K31/58 ,  A61K31/585 ,  A61K9/00 ,  A61K9/16

CPC分类号： A61K31/58 ,  A61K9/0024 ,  A61K9/1647 ,  A61K31/585 ,  A61K47/34

摘要： Effective treatments of pain and inflammation are provided. Through the administration of an effective amount of fluocinolone at or near a target site, one can reduce, prevent or treat inflammation and pain and autoimmune disorders. In various embodiments, fluocinolone formulations may be provided within biodegradable polymers to reduce, prevent or treat sciatic pain and/or inflammation. In various embodiments, prevent transplant rejection for at least twenty-five days. In some embodiments, the pain relief can be for at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.

摘要翻译： 提供有效的疼痛和炎症治疗。 通过在靶位点附近施用有效量的氟轻松，可以减少，预防或治疗炎症和疼痛以及自身免疫性疾病。 在各种实施方案中，可以在可生物降解的聚合物内提供氟轻松制剂以减少，预防或治疗坐骨神经痛和/或炎症。 在各种实施方案中，防止移植排斥至少二十五天。 在一些实施方案中，疼痛缓解可以是至少五十天，至少一百天，至少一百三十五天或至少一百八十天。