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公开(公告)号:US20100209358A1
公开(公告)日:2010-08-19
申请号:US12767530
申请日:2010-04-26
IPC分类号: A61K9/12 , A61K9/14 , A61K31/225
CPC分类号: A61K9/5115 , A61K9/0075 , A61K9/008 , A61K9/145 , A61K9/1617 , A61K9/167 , A61K9/50 , A61K9/501 , A61K9/5015 , A61K9/5089 , A61K31/137 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/32
摘要: The invention relates to a method for making composite active particles for use in a pharmaceutical composition for pulmonary administration, the method comprising a milling step in which particles of active material are milled in the presence of particles of an additive material which is suitable for the promotion of the dispersal of the composite active particles upon actuation of an inhaler. The invention also relates to compositions for inhalation prepared by the method.
摘要翻译: 本发明涉及一种用于制备用于肺部给药的药物组合物的复合活性颗粒的方法,所述方法包括研磨步骤,其中活性物质的颗粒在适于促进的添加剂材料的颗粒存在下研磨 在吸入器致动时复合活性颗粒的分散。 本发明还涉及通过该方法制备的用于吸入的组合物。