公开(公告)号：US07456160B2

公开(公告)日：2008-11-25

申请号：US10872784

申请日：2004-06-22

申请人： John R Evans ,  Rosalind U Grundy

发明人： John R Evans ,  Rosalind U Grundy

IPC分类号： A61K31/56

CPC分类号： A61K9/0019 ,  A61K31/565 ,  A61K47/10 ,  A61K47/14 ,  A61K47/44

摘要： The invention relates to a novel sustained release pharmaceutical formulation adapted for administration by injection containing the compound 7α-[9-(4,4,5,5,5-pentafluoropentylsulphinyl)nonyl]oestra-1,3,5(10)-triene-3,17β-diol, more particularly to a formulation adapted for administration by injection containing the compound 7α-[9-(4,4,5,5,5-pentafluoropentylsulphinyl)nonyl]oestra-1,3,5(10)-triene-3,17β-diol in solution in a ricinoleate vehicle which additionally comprises at least one alcohol and a non-aqueous ester solvent which is miscible in the ricinoleate vehicle.

摘要翻译： 本发明涉及适于通过注射给药的新型缓释药物制剂，其含有化合物7α-[9-（4,4,5,5,5-五氟戊基亚磺酰基）壬基]雌甾-1,3,5（10） - 三烯 -3bβ-二醇，更具体地说，涉及一种适于通过注射给药的制剂，其中含有化合物7α-[9-（4,4,5,5,5-五氟戊基亚磺酰基）壬基]雌甾-1,3,5（10） 三烯-3,17b-二醇在蓖麻油酸酯载体中的溶液中，其另外包含至少一种醇和在蓖麻酸酯载体中可混溶的非水酯溶剂。

公开(公告)号：US06774122B2

公开(公告)日：2004-08-10

申请号：US09756291

申请日：2001-01-09

申请人： John R Evans ,  Rosalind U Grundy

发明人： John R Evans ,  Rosalind U Grundy

IPC分类号： A61K3156

CPC分类号： A61K9/0019 ,  A61K31/565 ,  A61K47/10 ,  A61K47/14 ,  A61K47/44

摘要： The invention relates to a novel sustained release pharmaceutical formulation adapted for administration by injection containing the compound 7&agr;-[9-(4,4,5,5,5-pentafluoropentylsulphinyl)nonyl]oestra-1,3,5(10)-triene-3,17&bgr;-diol, more particularly to a formulation adapted for administration by injection containing the compound 7&agr;-[9-(4,4,5,5,5-pentafluoropentylsulphinyl)nonyl]oestra-1,3,5(10)-triene-3,17&bgr;-diol in solution in a ricinoleate vehicle which additionally comprises at least one alcohol and a non-aqueous ester solvent which is miscible in the ricinoleate vehicle.

摘要翻译： 本发明涉及适于通过注射给药的新型缓释药物制剂，其含有化合物7α-[9-（4,4,5,5,5-五氟戊基亚磺酰基）壬基]雌甾-1,3,5（10） - 三烯 -3bβ-二醇，更具体地说，涉及一种适于通过注射给药的制剂，其中含有化合物7α-[9-（4,4,5,5,5-五氟戊基亚磺酰基）壬基]雌甾-1,3,5（10） 三烯-3,17b-二醇在蓖麻油酸酯载体中的溶液中，其另外包含至少一种醇和在蓖麻酸酯载体中可混溶的非水酯溶剂。

公开(公告)号：US08466139B2

公开(公告)日：2013-06-18

申请号：US13602667

申请日：2012-09-04

申请人： John R Evans ,  Rosalind U Grundy

发明人： John R Evans ,  Rosalind U Grundy

IPC分类号： A61K31/56

CPC分类号： A61K9/0019 ,  A61K31/565 ,  A61K47/10 ,  A61K47/14 ,  A61K47/44

摘要： The invention relates to a novel sustained release pharmaceutical formulation adapted for administration by injection containing the compound 7α-[9-(4,4,5,5,5-pentafluoropentylsulphinyl)nonyl]oestra-1,3,5(10)-triene-3,17β-diol, more particularly to a formulation adapted for administration by injection containing the compound 7α-[9-(4,4,5,5,5-pentafluoropentylsulphinyl)nonyl]oestra-1,3,5(10)-triene-3,17β-diol in solution in a ricinoleate vehicle which additionally comprises at least one alcohol and a non-aqueous ester solvent which is miscible in the ricinoleate vehicle.

摘要翻译： 本发明涉及适于通过注射给药的新型缓释药物制剂，其含有化合物7α-[9-（4,4,5,5,5-五氟戊基亚磺酰基）壬基]雌甾-1,3,5（10） - 三烯 -3bβ-二醇，更具体地说，涉及一种适于通过注射给药的制剂，其中含有化合物7α-[9-（4,4,5,5,5-五氟戊基亚磺酰基）壬基]雌甾-1,3,5（10） 三烯-3,17b-二醇在蓖麻油酸酯载体中的溶液中，其另外包含至少一种醇和在蓖麻酸酯载体中可混溶的非水酯溶剂。

公开(公告)号：US08329680B2

公开(公告)日：2012-12-11

申请号：US12285887

申请日：2008-10-15

申请人： John R Evans ,  Rosalind U Grundy

发明人： John R Evans ,  Rosalind U Grundy

IPC分类号： A61K31/56

CPC分类号： A61K9/0019 ,  A61K31/565 ,  A61K47/10 ,  A61K47/14 ,  A61K47/44

摘要： The invention relates to a novel sustained release pharmaceutical formulation adapted for administration by injection containing the compound 7α-[9-(4,4,5,5,5-pentafluoropentylsulphinyl)nonyl]oestra-1,3,5(10)-triene-3,17β-diol, more particularly to a formulation adapted for administration by injection containing the compound 7α-[9-(4,4,5,5,5-pentafluoropentylsulphinyl)nonyl]oestra-1,3,5(10)-triene-3,17β-diol in solution in a ricinoleate vehicle which additionally comprises at least one alcohol and a non-aqueous ester solvent which is miscible in the ricinoleate vehicle.

摘要翻译： 本发明涉及一种适于通过注射给药的新型缓释药物制剂，其含有化合物7α-[9-（4,4,5,5,5-五氟戊基亚磺酰基）壬基]雌甾-1,3,5（10） - 三烯 更具体地说，涉及一种适于通过注射给药的制剂，其中含有化合物7α-[9-（4,4,5,5,5-五氟戊基亚磺酰基）壬基]雌甾-1,3,5（10 ） - 三烯-3,17＆bgr二醇在蓖麻油酸酯载体中的溶液中，其另外包含至少一种醇和在蓖麻酸酯载体中可混溶的非水性酯溶剂。