公开(公告)号：US06734312B2

公开(公告)日：2004-05-11

申请号：US10325424

申请日：2002-12-20

申请人： John R. Reynolds ,  Bert Groenendaal ,  Kyukwan Zong ,  Luis Madrigal

发明人： John R. Reynolds ,  Bert Groenendaal ,  Kyukwan Zong ,  Luis Madrigal

IPC分类号： C07D49502

CPC分类号： C07D491/04 ,  C07D495/04

摘要： A process for preparing a heteroaromatic compound having a heteroaromatic nucleus substituted with one or more ether groups comprising the step of: condensing at least one hydroxy-group of a compound having said heteroaromatic nucleus, said at least one hydroxy group (—OH) being substituted at &agr;- or &bgr;-positions with respect to a heteroatom of said heteroaromatic nucleus, with an alcohol containing one or more primary or secondary alcohol groups, optionally substituted with nitro, amide, ester, halogen, cyano or (hetero)aromatic groups, using the redox couple of a triaryl- or trialkylphosphine and an azodioxo-compound at a temperature between −40° C. and 160° C.

摘要翻译： 一种制备具有被一个或多个醚基取代的杂芳族核的杂芳族化合物的方法，包括以下步骤：将具有所述杂芳族核的化合物的至少一个羟基缩合，所述至少一个羟基（-OH）被取代 含有一个或多个伯或仲醇基的醇，任选被硝基，酰胺，酯，卤素，氰基或（杂）芳族基团取代的醇，使用在所述杂芳族核的杂原子的α位或β位上，使用 在-40℃至160℃的温度下，三芳基 - 或三烷基膦和偶氮二氧化合物的氧化还原对。