公开(公告)号：US08637047B2

公开(公告)日：2014-01-28

申请号：US10975702

申请日：2004-10-28

申请人： John Randall Swart ,  Eric Martin Vaughn ,  Karen E. Freking ,  Michael B. Roof ,  Phillip Wayne Hayes ,  Reid C. Phillips

发明人： John Randall Swart ,  Eric Martin Vaughn ,  Karen E. Freking ,  Michael B. Roof ,  Phillip Wayne Hayes ,  Reid C. Phillips

IPC分类号： A61K39/116 ,  A61K39/102

CPC分类号： A61K39/102 ,  A61K39/0241 ,  A61K2039/54 ,  A61K2039/552 ,  A61K2039/55566

摘要： The present invention provides a composition and an improved single dose vaccine against E. rhusiopathiae and an improved single dose vaccine against E. rhusiopathiae and H. parasuis which provides one or more of the following: 1) confers effective immunity against E. rhusiopathiae and/or H. parasuis; 2) decreases the risk of developing clinical signs of E. rhusiopathiae and/or H. parasuis infection; 3) induces an immune response against E. rhusiopathiae and/or H. parasuis; and 4) has a DOI against E. rhusiopathiae and/or H. parasuis of at least four months. The composition or E. rhusiopathiae vaccine as well as the combined E. rhusiopathiae-H. parasuis composition or vaccine each includes a bacterial component of inactivated E. rhusiopathiae bacteria and a suitable adjuvant. The combined E. rhusiopathiae-H. parasuis composition or vaccine further includes an amount of H. parasuis antigen. The vaccines can be administered to animals in any conventional manner. The amount of the dose for intramuscular administration is preferably less than 5 ml. The amount of E. rhusiopathiae and/or H. parasuis antigen in each dose should be enough to induce an immune response in the animal receiving the vaccine or composition and will preferably confer effective immunity against and decrease the risk of developing clinical signs resulting from E. rhusiopathiae and/or H. parasuis infection for a suitable duration of immunity.

摘要翻译： 本发明提供组合物和改进的针对埃氏杆菌病的单一剂量疫苗和针对针对埃希氏杆菌和副猪嗜血杆菌的改进的单剂量疫苗，其提供以下一种或多种：1）赋予针对E.杆菌病和/ 或副猪嗜血菌 2）降低发生脑炎病毒和/或副猪嗜血杆菌感染的临床症状的风险; 3）诱导针对埃氏杆菌和/或副猪嗜血杆菌的免疫应答; 和4）具有至少四个月的针对埃氏杆菌和/或副猪嗜血杆菌的DOI。 组合物或E.杆菌病疫苗以及组合的脑炎病毒H。 副产物组合物或疫苗各自包括灭活的肠球菌属细菌的细菌组分和合适的佐剂。 合并的脑炎病毒H。 副产物组成或疫苗还包括一定量的副猪嗜血杆菌抗原。 疫苗可以以任何常规方式施用于动物。 肌内给药的剂量优选小于5ml。 每种剂量的肠球菌和/或副猪嗜血杆菌抗原的量应足以在接受疫苗或组合物的动物中诱导免疫应答，并且优选地赋予有效的免疫力并降低由E引起的临床体征的风险 rhusiopathiae和/或副猪嗜血杆菌感染，具有合适的免疫持续时间。