公开(公告)号：US06982157B1

公开(公告)日：2006-01-03

申请号：US09889414

申请日：2000-02-01

申请人： John S Pears ,  Ali Raza ,  Howard G Hutchinson ,  Dennis Schneck ,  Takahiko Baba ,  Akira Touchi

发明人： John S Pears ,  Ali Raza ,  Howard G Hutchinson ,  Dennis Schneck ,  Takahiko Baba ,  Akira Touchi

IPC分类号： C12N9/99

CPC分类号： A61K45/06 ,  A61K31/365

摘要： The invention concerns safe non-interacting drug combinations of a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, which is (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5 -dihydroxyhept-6-enoic acid or a pharmaceutically acceptable salt thereof (the Agent) and a drug which is either an inducer, inhibitor or a substrate of cytochrome P450, in particular cytochrome P450 isoenzyme 3A4. Particular combinations are useful in treating hyperlipidaemia in humans who are receiving immunosuppressive chemotherapy. A preferred combination is the Agent and a fibrate drug, the use of such a combination in treating hyperlipidaemia in mammals, and medicaments containing such a combination for use in such treatments.

摘要翻译： 本发明涉及3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶抑制剂的安全的非相互作用药物组合，其是（E）-7- [4-（4-氟苯基）-6-异丙基-2 - [甲基（甲基磺酰基）氨基]嘧啶-5-基]（3R，5S）-3,5-二羟基庚-6-烯酸或其药学上可接受的盐（该试剂）和作为诱导剂，抑制剂 或细胞色素P450的底物，特别是细胞色素P450同工酶3A4。 特殊的组合可用于治疗正在接受免疫抑制化疗的人中的高脂血症。 优选的组合是药剂和贝特类药物，这种组合在哺乳动物中治疗高脂血症的用途，以及含有用于这种治疗的组合的药物。