Enhancing recombinant hemoglobin production by co-expression with alpha hemoglobin stabilizing protein
    1.
    发明授权
    Enhancing recombinant hemoglobin production by co-expression with alpha hemoglobin stabilizing protein 失效
    通过与α血红蛋白稳定蛋白共表达来增强重组血红蛋白的产生

    公开(公告)号:US07642233B2

    公开(公告)日:2010-01-05

    申请号:US11685986

    申请日:2007-03-14

    IPC分类号: C07K14/00

    CPC分类号: C07K14/805

    摘要: The present disclosure relates to the use of AHSP to stabilize the α subunit of rHb. AHSP may be co-expressed with the hemoglobin genes. AHSP stabilization may be used to increase the production of intact rHb in various systems, such as E. coli, other microorganisms, or animal erythroid cells. This intact rHb may then be used as part of a blood substitute product.

    摘要翻译: 本公开涉及AHSP用于稳定rHb的α亚基的用途。 AHSP可以与血红蛋白基因共表达。 可以使用AHSP稳定化来增加各种系统如大肠杆菌,其他微生物或动物红细胞中完整rHb的产生。 然后可将该完整的rHb用作血液替代品的一部分。