公开(公告)号：US06835728B2

公开(公告)日：2004-12-28

申请号：US10181843

申请日：2002-10-08

Applicant: John Stuart Andrews ,  Wilhelmus Drinkenburg ,  Nicholas Matthew Ward

Inventor： John Stuart Andrews ,  Wilhelmus Drinkenburg ,  Nicholas Matthew Ward

IPC: A61K3155

CPC classification number: A61K31/55 ,  Y10S514/922 ,  A61K31/505 ,  A61K2300/00

Abstract: The invention relates to a combination comprising an amount of mirtazapine, or a pharmaceutically acceptable salt or solvate thereof, and an amount of gepirone, or a pharmaceutically acceptable salt or solvate thereof, optionally in association with one or more pharmaceutically acceptable carriers, whereby the amount of gepirone and the amount of mirtazapine are such that the effect of the composition is more favourable than the added effects of the amounts of each drug separately. This combination can be used in the treatment of depression and related disorders, whereby the invention also provides for a new method of treatment of depression and related disorders.

Abstract translation: 本发明涉及一种组合，其包含一定量的米氮平或其药学上可接受的盐或溶剂化物，以及任选地与一种或多种药学上可接受的载体结合的吉哌隆或其药学上可接受的盐或溶剂合物的量， 的吉非隆和米氮平的量使得组合物的效果比每种药物的量的添加效果更有利。 这种组合可用于治疗抑郁症和相关疾病，由此本发明还提供治疗抑郁症和相关疾病的新方法。

公开(公告)号：US06303595B1

公开(公告)日：2001-10-16

申请号：US09554143

申请日：2000-07-14

Applicant: John Stuart Andrews

Inventor： John Stuart Andrews

IPC: A61K3155

CPC classification number: A61K31/00 ,  A61K31/55

Abstract: The compound mirtazapine is found to be effective in treating sleep apneas. Optionally, mirtazapine is combined with an SSRI such as fluoxetin.

Abstract translation: 发现复方米氮平可以有效治疗睡眠呼吸暂停。 任选地，米氮平与SSRI如氟西汀组合。