公开(公告)号：US20110125012A1

公开(公告)日：2011-05-26

申请号：US12916326

申请日：2010-10-29

申请人： Jon Erik BRAENDEN ,  Aslak Godal ,  Nils Olav Nilsen ,  Jo Klaveness

发明人： Jon Erik BRAENDEN ,  Aslak Godal ,  Nils Olav Nilsen ,  Jo Klaveness

IPC分类号： A61B6/00 ,  C12Q1/02 ,  G01N21/64 ,  A61M37/00

CPC分类号： A61K41/0061 ,  C07C229/22

摘要： The present invention provides an acid addition salt of 5-aminolevulinic acid (5-ALA) or of a 5-ALA derivative (e.g. a 5-ALA ester) with an acid which has a pKa of about 5 or less, preferably about 3 or less, with the proviso that the acid is other than hydrochloric acid. Particularly preferred salts are those derived from acids selected from the group comprising sulphonic acid and its derivatives, hydrobromic acid, sulfuric acid, nitric acid and phosphoric acid. The salts in accordance with the invention are particularly suitable for use as photosensitizing agents in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body.

摘要翻译： 本发明提供5-氨基乙酰丙酸（5-ALA）或5-ALA衍生物（例如5-ALA酯）与酸的加成盐，所述酸的pKa为约5或更小，优选约3或 较少，条件是酸不是盐酸。 特别优选的盐是衍生自选自磺酸及其衍生物，氢溴酸，硫酸，硝酸和磷酸的酸的酸。 根据本发明的盐特别适用于诊断和光化学治疗身体的外表面或内表面的病症或异常的光敏剂。