公开(公告)号：US20100249107A1

公开(公告)日：2010-09-30

申请号：US12438457

申请日：2007-08-17

Applicant: Jonathan Benjamin Singer

Inventor： Jonathan Benjamin Singer

IPC: A61K31/55 ,  C07C271/40 ,  A61K31/27 ,  A61K31/435 ,  A61K31/4353 ,  A61K31/13 ,  G01N33/50 ,  A61P25/28

CPC classification number: A61K31/222 ,  Y10T436/143333

Abstract: This invention relates generally to the analytical testing of tissue samples in vitro, and more particularly to aspects of genetic polymorphisms associated with the conversion from Mile Cognitive Impairment to dementia, e.g., Alzheimer's Disease (AD). The invention provides AD-associated mutations which are useful in the diagnosis, prognosis or therapeutic treatment of dementia, e.g., Alzheimer's Disease.

Abstract translation: 本发明一般涉及体外组织样品的分析测试，更具体地涉及与从Mile认知障碍转化为痴呆（例如阿尔茨海默氏病（AD））相关的遗传多态性的方面。 本发明提供了可用于痴呆症例如阿尔茨海默氏病的诊断，预后或治疗性治疗的AD相关突变。