公开(公告)号：US20080139655A1

公开(公告)日：2008-06-12

申请号：US11850063

申请日：2007-09-05

申请人： Jonathan Bortz ,  Michael Grimshaw ,  David F. Erkoboni ,  Michael F. Dickus

发明人： Jonathan Bortz ,  Michael Grimshaw ,  David F. Erkoboni ,  Michael F. Dickus

IPC分类号： A61K31/195 ,  A61P25/28

CPC分类号： A61K31/198 ,  A61K9/0065 ,  A61K9/205 ,  A61K9/2054

摘要： A pharmaceutical composition comprising levodopa is provided that, when administered in a unit dosage amount of levodopa of about 100 to about 500 mg at a dosage interval of about 6 to about 24 hours, exhibits a sufficiently long release period and a sufficiently long residence time in the upper gastrointestinal tract to provide a trough concentration of levodopa in plasma of the subject that is not lower than a minimum threshold concentration below which adverse motor effects are observed in the subject. A method for treating Parkinson's disease in a subject is also provided, comprising orally administering such a composition to the subject in a unit dosage amount of levodopa of about 50 to about 1000 mg at a dosage interval of about 3 to about 24 hours.

摘要翻译： 提供包含左旋多巴的药物组合物，其以约6至约24小时的剂量间隔以约100至约500mg的单位剂量的左旋多巴施用时，显示足够长的释放期和足够长的停留时间 上消化道提供受试者血浆中左旋多巴的谷浓度，其不低于在受试者中观察到不良运动效应的最低阈值浓度。 还提供了治疗受试者中帕金森病的方法，其包括以约3至约24小时的剂量间隔以约50至约1000mg的单位剂量的左旋多巴口服施用该组合物。