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![Azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]-quinoline as 5-HT1A antagonists](/abs-image/US/2004/11/23/US06821981B2/abs.jpg.150x150.jpg)
1.发明授权Azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]-quinoline as 5-HT1A antagonists 失效2,3-二氢-1,4-二氧杂环己烯并[2,3-f] - 喹啉的5-氮杂杂环甲基衍生物作为5-HT 1A拮抗剂公开(公告)号：US06821981B2
公开(公告)日：2004-11-23
申请号：US10131997
申请日：2002-04-25
IPC分类号： C07D49104
CPC分类号： C07D491/04 , A61K31/335 , A61K31/44 , A61K2300/00
摘要： Compounds of the formula useful for the treatment of disorders, such as anxiety, aggression and stress, and for the control of various physiological phenomena, such as appetite, thermoregulation, sleep and sexual behavior.
摘要翻译： 适用于治疗诸如焦虑，侵略和压力等疾病以及控制各种生理现象（如食欲，体温调节，睡眠和性行为）的化合物。
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![Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-Dioxino[2,3-f]quinoxaline](/abs-image/US/2006/03/07/US07008944B2/abs.jpg.150x150.jpg)
2.发明授权Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-Dioxino[2,3-f]quinoxaline 失效2,3-二氢-1,4-二氧杂环己烯并[2,3-f]喹喔啉的抗抑郁药氮杂环甲基衍生物公开(公告)号：US07008944B2
公开(公告)日：2006-03-07
申请号：US10618947
申请日：2003-07-14
申请人： Jonathan L. Gross , Gary P. Stack
发明人： Jonathan L. Gross , Gary P. Stack
IPC分类号： A01N43/58 , A01N43/60 , A61K31/495 , A61K31/50
CPC分类号： C07D491/04
摘要： Compounds of the formula: are useful for the treatment of depression and other diseases such as obsessive compulsive disorder, panic attacks, generalized anxiety disorder, social anxiety disorder, sexual dysfunction, eating disorders, obesity, addictive disorders caused by ethanol or cocaine abuse and related illnesses.
摘要翻译： 下式的化合物可用于治疗抑郁症和其他疾病，如强迫症，恐慌发作，广泛性焦虑症，社会焦虑症，性功能障碍，饮食失调，肥胖症，乙醇或可卡因滥用引起的成瘾性疾病及相关 疾病
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公开(公告)号：US06700001B2
公开(公告)日：2004-03-02
申请号：US10264947
申请日：2002-10-04
申请人： Jonathan L. Gross , Gary P. Stack
发明人： Jonathan L. Gross , Gary P. Stack
IPC分类号： C07D31158
CPC分类号： C07D491/04 , C07D311/04 , C07D311/58
摘要： A process for the stereoselective synthesis of 2-hydroxymethyl-chromans of formula (II) is provided where R, R1, R2 and R3 are as defined herein. The compound of formula (II) is prepared using an optically active benzene compound of formula (I) where R0 is as defined herein. The 2-hydroxymethyl-chroman compounds of formula (II) are useful as intermediates for preparing a variety of medicinal agents.
摘要翻译： 提供了立体选择性合成式（II）的2-羟甲基 - 苯并二氢吡喃酮的方法，其中R，R 1，R 2和R 3如本文所定义。 式（II）化合物使用式（I）的光学活性苯化合物制备，其中R 0如本文所定义。 式（II）的2-羟甲基 - 苯并二氢吡喃化合物可用作制备各种药剂的中间体。
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![Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]quinoxaline](/abs-image/US/2003/09/09/US06617327B2/abs.jpg.150x150.jpg)
4.发明授权Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]quinoxaline 失效2,3-二氢-1,4-二氧杂环己烯并[2,3-f]喹喔啉的抗抑郁药氮杂环甲基衍生物公开(公告)号：US06617327B2
公开(公告)日：2003-09-09
申请号：US10128722
申请日：2002-04-23
申请人： Jonathan L. Gross , Gary P. Stack
发明人： Jonathan L. Gross , Gary P. Stack
IPC分类号： A61K314985
CPC分类号： C07D491/04
摘要： Compounds of the formula: are useful for the treatment of depression and other diseases such as obsessive compulsive disorder, panic attacks, generalized anxiety disorder, social anxiety disorder, sexual dysfunction, eating disorders, obesity, addictive disorders caused by ethanol or cocaine abuse and related illnesses.
摘要翻译： 下式的化合物可用于治疗抑郁症和其他疾病，如强迫症，恐慌发作，广泛性焦虑症，社会焦虑症，性功能障碍，饮食失调，肥胖症，乙醇或可卡因滥用引起的成瘾性疾病及相关 疾病
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公开(公告)号：US06716998B2
公开(公告)日：2004-04-06
申请号：US10264528
申请日：2002-10-04
申请人： Jonathan L. Gross
发明人： Jonathan L. Gross
IPC分类号： C07D31104
CPC分类号： C07D311/58 , C07D311/64 , C07D405/04
摘要： This invention provides a process for the stereospecific preparation of 2-yl-chroman and -chromene derivatives of the formula: These compounds are useful for the preparation of optically active 2-aminomethyl- and 2-azaheterocyclylmethyl-chromans.
摘要翻译： 本发明提供了下式的2-基 - 苯并二氢吡喃衍生物的立体选择性制备方法：这些化合物可用于制备光学活性2-氨基甲基 - 和2-氮杂环丙基甲基 - 苯并二氢吡喃酮。
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