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8 条记录 (耗时 0.019 秒)

    Production of Dosing Molds from Active Substance-Containing Melts
    1.
    发明申请
    Production of Dosing Molds from Active Substance-Containing Melts 审中-公开
    从含活性物质的熔体生产计量模具

    公开(公告)号：US20090050262A1

    公开(公告)日：2009-02-26

    申请号：US11884521

    申请日：2006-02-17

    申请人： Jorg Rosenberg ,  Norbert Steiger ,  Harald Hach ,  Jorg Breitenbach

    发明人： Jorg Rosenberg ,  Norbert Steiger ,  Harald Hach ,  Jorg Breitenbach

    IPC分类号： B32B37/10

    CPC分类号： A61J3/10 ,  A61J2200/20 ,  B30B11/16

    摘要： Disclosed is a method for producing dosing molds, according to which two separating films (7) are contacted with each other in a defined area, an active substance-containing melt is introduced between the separating films (7) such that a pocket for receiving a portion of the melt is embodied in at least one of the separating films, and the separating films (7) are separated from each other in order to eject the portion. Preferably, a method is disclosed in which the separating films (7) are contacted with each other in the gap of two molding rolls (2, 3) which rotate in opposite directions and are provided with opposite recesses (4, 5) on the surface thereof, and into which the separating films (7) can be pressed when the active substance-containing melt is introduced so as to form pockets. The separating films (7) make it possible to avoid a direct contact between the melt and the rolls (4,5) and thus prevent the melt from adhering to the roll (2, 3). Elastically deformable separating films (7) support the ejection process as a result of the stress thereof being released after leaving the roll gap (2, 3).

    摘要翻译： 公开了一种用于生产定量给料模具的方法，根据该方法，两个分离膜（7）在限定的区域中彼此接触，含活性物质的熔体被引入到分离膜（7）之间，使得用于接收 熔体的一部分体现在至少一个分离膜中，并且分离膜（7）彼此分离以便喷射该部分。 优选地，公开了一种方法，其中分离膜（7）在沿相反方向旋转的两个成型辊（2,3）的间隙中彼此接触并且在表面上设置有相对的凹部（4,5） 并且当引入含活性物质的熔体以形成袋时，分离膜（7）可以被压入其中。 分离膜（7）使得可以避免熔体与辊（4,5）之间的直接接触，从而防止熔体粘附到辊（2,3）上。 弹性变形分离膜（7）由于在离开辊间隙（2,3）之后其应力释放而支持喷射过程。

    PREPARATION OF COMPOSITIONS WITH ESSENTIALLY NONCRYSTALLINE EMBEDDED MACROLIDE ANTIBIOTICS
    4.
    发明申请
    PREPARATION OF COMPOSITIONS WITH ESSENTIALLY NONCRYSTALLINE EMBEDDED MACROLIDE ANTIBIOTICS 有权
    具有非天然嵌合抗体的组合物的制备

    公开(公告)号：US20120001361A1

    公开(公告)日：2012-01-05

    申请号：US12673230

    申请日：2008-08-14

    申请人： Ulrich Westedt ,  Jörg Rosenberg ,  Martin Knobloch ,  Norbert Steiger ,  Harald Hach

    发明人： Ulrich Westedt ,  Jörg Rosenberg ,  Martin Knobloch ,  Norbert Steiger ,  Harald Hach

    IPC分类号： B29C47/36

    CPC分类号： A61K9/146 ,  B29C47/40 ,  B29C47/6056 ,  B29C47/64

    摘要： A description is given of a process for the preparation of a pharmaceutical composition of a macrolide antibiotic in essentially noncrystalline form, in which the macrolide antibiotic, a water-swellable polymer and a proton donor are blended in an extruder in the presence of water and forced through a die, the ratio by weight of the sum of macrolide antibiotic, water-swellable polymer and proton donor to water being at least 1:1. The macrolide antibiotic is preferably clarithromycin and the water-swellable polymer is preferably chosen from crosslinked polyvinylpyrrolidone, crosslinked sodium carboxymethylcellulose and crosslinked polyacrylic acid.

    摘要翻译： 描述了制备基本上非结晶形式的大环内酯类抗生素药物组合物的方法，其中大环内酯类抗生素，水溶胀性聚合物和质子供体在水和挤出机的存在下在挤出机中共混 通过模具，大环内酯类抗生素，水溶胀性聚合物和质子供体与水的总量的重量比至少为1:1。 大环内酯类抗生素优选为克拉霉素，并且水溶胀性聚合物优选选自交联聚乙烯吡咯烷酮，交联羧甲基纤维素钠和交联聚丙烯酸。

    Preparation of compositions with essentially noncrystalline embedded macrolide antibiotics
    5.
    发明授权
    Preparation of compositions with essentially noncrystalline embedded macrolide antibiotics 有权
    具有基本上非晶体嵌入的大环内酯类抗生素的组合物的制备

    公开(公告)号：US08337733B2

    公开(公告)日：2012-12-25

    申请号：US12673230

    申请日：2008-08-14

    申请人： Ulrich Westedt ,  Jörg Rosenberg ,  Martin Knobloch ,  Norbert Steiger ,  Harald Hach

    发明人： Ulrich Westedt ,  Jörg Rosenberg ,  Martin Knobloch ,  Norbert Steiger ,  Harald Hach

    IPC分类号： B29C47/00

    CPC分类号： A61K9/146 ,  B29C47/40 ,  B29C47/6056 ,  B29C47/64

    摘要： A description is given of a process for the preparation of a pharmaceutical composition of a macrolide antibiotic in essentially noncrystalline form, in which the macrolide antibiotic, a water-swellable polymer and a proton donor are blended in an extruder in the presence of water and forced through a die, the ratio by weight of the sum of macrolide antibiotic, water-swellable polymer and proton donor to water being at least 1:1. The macrolide antibiotic is preferably clarithromycin and the water-swellable polymer is preferably chosen from crosslinked polyvinylpyrrolidone, crosslinked sodium carboxymethylcellulose and crosslinked polyacrylic acid.

    摘要翻译： 描述了制备基本上非结晶形式的大环内酯类抗生素药物组合物的方法，其中大环内酯类抗生素，水溶胀性聚合物和质子供体在水和挤出机的存在下在挤出机中共混 通过模具，大环内酯类抗生素，水溶胀性聚合物和质子供体与水的总量的重量比至少为1:1。 大环内酯类抗生素优选为克拉霉素，水溶胀性聚合物优选选自交联聚乙烯吡咯烷酮，交联羧甲基纤维素钠和交联聚丙烯酸。