公开(公告)号：US08237106B2

公开(公告)日：2012-08-07

申请号：US12299996

申请日：2007-05-10

申请人： Jose M. Castro-Perez ,  Jane Kirby ,  John Philip Edward Shockcor

发明人： Jose M. Castro-Perez ,  Jane Kirby ,  John Philip Edward Shockcor

IPC分类号： B01D59/44

CPC分类号： H01J49/42 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/0045

摘要： A mass spectrometer comprising a collision, fragmentation or reaction cell (4) is disclosed. The collision, fragmentation or reaction cell (4) is repeatedly switched back and forth between a high fragmentation mode of operation and a low fragmentation mode of operation. Mass spectral data sets are obtained in both modes of operation. A decimal mass filter is applied to one or both sets of data. In particular, fragment ions or metabolites related to a parent or precursor ion of interest are identified on the basis of having a decimal mass which is similar to that of the parent or precursor ion of interest.

摘要翻译： 公开了一种包含碰撞，碎裂或反应池（4）的质谱仪。 碰撞，破碎或反应池（4）在高碎裂操作模式和低碎裂操作模式之间来回重复切换。 在两种操作模式下获得质谱数据集。 十进制质量过滤器应用于一组或两组数据。 特别地，与目标亲本或前体离子相关的片段离子或代谢物基于具有与感兴趣的亲本或前体离子的十进制质量相似的十进制质量来鉴定。

公开(公告)号：US20090302210A1

公开(公告)日：2009-12-10

申请号：US12299996

申请日：2007-05-10

申请人： Jose M. Castro-Perez ,  Jane Kirby ,  John Shockcor

发明人： Jose M. Castro-Perez ,  Jane Kirby ,  John Shockcor

IPC分类号： H01J49/26

CPC分类号： H01J49/42 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/0045

摘要： A mass spectrometer comprising a collision, fragmentation or reaction cell (4) is disclosed. The collision, fragmentation or reaction cell (4) is repeatedly switched back and forth between a high fragmentation mode of operation and a low fragmentation mode of operation. Mass spectral data sets are obtained in both modes of operation. A decimal mass filter is applied to one or both sets of data. In particular, fragment ions or metabolites related to a parent or precursor ion of interest are identified on the basis of having a decimal mass which is similar to that of the parent or precursor ion of interest.

摘要翻译： 公开了一种包含碰撞，碎裂或反应池（4）的质谱仪。 碰撞，破碎或反应池（4）在高碎裂操作模式和低碎裂操作模式之间来回重复切换。 在两种操作模式下获得质谱数据集。 十进制质量过滤器应用于一组或两组数据。 特别地，与目标亲本或前体离子相关的片段离子或代谢物基于具有与感兴趣的亲本或前体离子的十进制质量相似的十进制质量来鉴定。

公开(公告)号：US20060118489A1

公开(公告)日：2006-06-08

申请号：US11210977

申请日：2005-08-24

申请人： Jose Castro-Perez ,  Robert Plumb ,  Jane Kirby

发明人： Jose Castro-Perez ,  Robert Plumb ,  Jane Kirby

IPC分类号： B01D15/08

CPC分类号： G01N30/8675 ,  G01N30/8617 ,  G01N30/8679

摘要： A method of rapidly analyzing unexpected metabolites in a metabolite analyzing system is disclosed. A control sample is run and analyzed to generate an exclusion list of unwanted sample components. A single analyte sample is then run and programmatically uses the exclusion list containing the unwanted metabolites to dynamically filter out data regarding components present in both the control sample and the analyte sample. The remaining components in the analyte sample are analyzed for unexpected metabolites of interest. The present invention allows for the analysis to be automated and eliminates the need for a second analyte sample run for the purpose of eliminating common components in the samples.

摘要翻译： 公开了一种在代谢分析系统中快速分析意外代谢物的方法。 运行和分析对照样品以产生不需要的样品组分的排除列表。 然后运行单个分析物样品，并以编程方式使用包含不需要的代谢物的排除列表，以动态过滤关于对照样品和分析物样品中存在的成分的数据。 分析分析物样品中的剩余组分，以获得意想不到的感兴趣的代谢物。 本发明允许分析自动化，并且消除了为了消除样品中的常见组分的目的而需要第二分析物样品运行。

公开(公告)号：US20070246427A1

公开(公告)日：2007-10-25

申请号：US11809067

申请日：2007-05-31

申请人： Jose Castro-Perez ,  Robert Plumb ,  Jane Kirby

发明人： Jose Castro-Perez ,  Robert Plumb ,  Jane Kirby

IPC分类号： B01D15/08

CPC分类号： G01N30/8675 ,  G01N30/8617 ,  G01N30/8679

摘要： A method of rapidly analyzing unexpected metabolites in a metabolite analyzing system is disclosed. A control sample is run and analyzed to generate an exclusion list of unwanted sample components. A single analyte sample is then run and programmatically uses the exclusion list containing the unwanted metabolites to dynamically filter out data regarding components present in both the control sample and the analyte sample. The remaining components in the analyte sample are analyzed for unexpected metabolites of interest. The present invention allows for the analysis to be automated and eliminates the need for a second analyte sample run for the purpose of eliminating common components in the samples.

摘要翻译： 公开了一种在代谢分析系统中快速分析意外代谢物的方法。 运行和分析对照样品以产生不需要的样品组分的排除列表。 然后运行单个分析物样品，并以编程方式使用包含不需要的代谢物的排除列表，以动态过滤关于对照样品和分析物样品中存在的成分的数据。 分析分析物样品中的剩余组分，以获得意想不到的感兴趣的代谢物。 本发明允许分析自动化，并且消除了为了消除样品中的常见组分的目的而需要第二分析物样品运行。