公开(公告)号：US5030724A

公开(公告)日：1991-07-09

申请号：US468412

申请日：1990-01-22

申请人： Joseph E. Sundeen ,  Robert Zahler ,  Stefan Jendrzejewski

发明人： Joseph E. Sundeen ,  Robert Zahler ,  Stefan Jendrzejewski

IPC分类号： A61K31/425 ,  A61P31/04 ,  C07C309/51 ,  C07C309/60 ,  C07D417/12 ,  C07D417/14

CPC分类号： C07D417/12 ,  C07C309/51

摘要： Antibacterial activity is exhibited by novel compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof. R.sub.3 and R.sub.4 are the same or different and each is hydrogen or alkyl or R.sub.3 and R.sub.4 taken together with the nitrogen atoms to which they are attached form a 1,2-diazacyclobutane, 1,2-diazacyclopentane, 1,2-diazacyclohexane, or 1,2-diazacycloheptane ring.Y.sub.1 and Y.sub.2 are either hydrogen or OR.sub.11 but are not the same.R.sub.11 is hydrogen, alkanoyl of from one to ten carbon atoms, substituted alkanoyl of from two to ten carbon atoms, phenylcarbonyl, (substituted phenyl) carbonyl, heteroarylcarbonyl, phenylalkanoyl, (substituted phenyl) alkanoyl, or heteroarylalkanoyl.

公开(公告)号：US5077432A

公开(公告)日：1991-12-31

申请号：US651871

申请日：1991-02-07

申请人： Joseph E. Sundeen ,  Robert Zahler ,  Stefan Jendrzejewski

发明人： Joseph E. Sundeen ,  Robert Zahler ,  Stefan Jendrzejewski

IPC分类号： C07C309/51 ,  C07D417/12

CPC分类号： C07D417/12 ,  C07C309/51

摘要： Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein R.sub.3 and R.sub.4 are the same or different and each is hydrogen or alkyl or R.sub.3 and R.sub.4 taken together with the nitrogen atoms to which they are attached form a 1,2-diazacyclobutane, 1,2-diazacyclopentane, 1,2-diazacyclohexane, or 1,2-diazacycloheptane ring and Y, and Y.sub.2 are either hydrogen or hydroxy but are not the same; are useful chemical intermediates for the preparation of .beta.-lactam antibiotics.

摘要翻译： 具有式“IMAGE”的化合物及其药学上可接受的盐，其中R 3和R 4相同或不同，并且各自为氢或烷基或R 3和R 4与它们所连接的氮原子一起形成1,2-二氮环丁烷 ，1,2-二氮杂环戊烷，1,2-二氮杂环己烷或1,2-二氮杂环庚烷环，Y和Y2分别是氢或羟基，但不相同; 是制备β-内酰胺抗生素的有用化学中间体。