公开(公告)号：US5425129A

公开(公告)日：1995-06-13

申请号：US968097

申请日：1992-10-29

申请人： Joseph H. Garman ,  Alice G. Klein ,  Vincent M. Stanford

发明人： Joseph H. Garman ,  Alice G. Klein ,  Vincent M. Stanford

IPC分类号： G10L15/04 ,  G10L15/00 ,  G10L15/08 ,  G10L15/10 ,  G10L15/14 ,  H04M3/42 ,  G10L5/06

CPC分类号： G10L15/142

摘要： A digitized speech data channel is analyzes for the presence of words or phrases from a desired list. If the word is not present the speech time series from the channel, there is a high probability of matching the input data to phonemic noise markers rather than to word models. This is accomplished through the use of a competitive algorithm wherein Hidden Markov Models (HMMs) of the desired words or phrases compete with an alternative HMM of a set of phonemes. The set of phonemes can be chosen in order to reduce the computer resources required for the channel analysis.

摘要翻译： 数字化语音数据信道是对来自期望列表的单词或短语的存在的分析。 如果该词不存在来自频道的语音时间序列，则将输入数据与音素噪声标记匹配的概率很高，而不是字模型。 这是通过使用竞争算法来实现的，其中期望的单词或短语的隐马尔科夫模型（HMM）与一组音素的替代HMM竞争。 可以选择一组音素，以减少频道分析所需的计算机资源。

公开(公告)号：US20100122907A1

公开(公告)日：2010-05-20

申请号：US12435667

申请日：2009-05-05

申请人： Vincent M. Stanford ,  John J. Kasianowicz ,  Joseph W.F. Robertson ,  Claudio G. Rodrigues ,  Oleg V. Krasilnikov

发明人： Vincent M. Stanford ,  John J. Kasianowicz ,  Joseph W.F. Robertson ,  Claudio G. Rodrigues ,  Oleg V. Krasilnikov

IPC分类号： G01N27/447

CPC分类号： G01N33/48721 ,  C12Q1/6869 ,  C12Q2537/165 ,  C12Q2563/116 ,  C12Q2565/631

摘要： A nanopore conductance measurement method and system is provided. The system has reservoirs of conductive fluid separated by a resistive barrier, which is perforated by a single nanometer scale pore commensurate in size with an analyte molecule in at least one of the reservoirs. The system is configured to have an ionic current driven across the reservoirs by an applied potential and the pore may be treated so that the pore surface can form associations with the analyte molecules of interest to increase the analyte molecule residence times on or in the pore. The system also comprises a means of measuring the ionic current, which current may be either direct or alternating in time, induced by an applied potential between electrodes in the conductive fluid, on each side of the barrier. The system also comprises a means of recording the ionic current time course as a time series, which includes time periods when the pore is unobstructed and also in periods when analyte molecules cause pulses of reduced conductance. The method comprises methods to delineate segments of the conductance time series into regions statistically consistent with the unobstructed pore conductance level, and pulses of reduced conductance, and also statistically stationary segments within individual pulses of reduced conductance. The method may also provide steps for interpreting the statistical analysis to yield parameters such as size, mass, and/or concentration of at least one type of analyte in solution.

摘要翻译： 提供纳米孔电导测量方法和系统。 该系统具有由电阻屏障分隔的导电流体的储存器，该电阻屏障通过与至少一个储存器中的分析物分子大小相当的单个纳米尺度孔穿孔。 该系统被配置为具有通过施加的电势驱动跨越储存器的离子电流，并且可以处理孔以使孔表面可以与感兴趣的分析物分子形成关联，以增加分析物分子在孔上或孔中的停留时间。 该系统还包括测量离子电流的手段，该电流可以是在屏障的每一侧上的导电流体中的电极之间的施加电位引起的时间上的直接或交替的电流。 该系统还包括将离子电流时间过程记录为时间序列的手段，时间序列包括当孔隙畅通的时间段以及分析物分子引起电导率降低的时段。 该方法包括将电导时间序列的段划分到与无阻碍的孔电导水平统计学一致的区域，以及降低的电导的脉冲以及降低的电导的单个脉冲内的统计学上固定的区段的方法。 该方法还可以提供解释统计分析以产生诸如解决方案中的至少一种类型的分析物的尺寸，质量和/或浓度的参数的步骤。

公开(公告)号：US5615296A

公开(公告)日：1997-03-25

申请号：US152654

申请日：1993-11-12

申请人： Vincent M. Stanford ,  Ora J. Williamson ,  Elton B. Sherwin, Jr. ,  Frank V. Castellucci

发明人： Vincent M. Stanford ,  Ora J. Williamson ,  Elton B. Sherwin, Jr. ,  Frank V. Castellucci

IPC分类号： G10L15/02 ,  G10L15/18 ,  G10L15/22 ,  G10L3/02 ,  G10L9/00 ,  G10L3/00

CPC分类号： G10L15/22 ,  G10L15/18

摘要： A continuous speech recognition and voice response system provides a natural sounding and effective interactive, speech-driven dialogue from a data processing system. A concatenation of words into phrases and sentences improves recognition and mimic natural language processing. The system uses speaker-independent, continuous-speech to initiate the playback of audio files. The system employs high-speed context switching to modify the active vocabulary and applies high-speed context switching to modify or activate Audio WAV voice response files. The system uses dialogue history to activate selected context, Baukus-Naur Form (BNF) grammars and WAV files and provides phrase or sentence long dialogue prompts to improve accuracy. The system also provides audio prompts to improve accuracy and provides speech-activated buttons to navigate between menus.

摘要翻译： 连续语音识别和语音响应系统提供了一种来自数据处理系统的自然发声和有效的交互式语音驱动对话。 将词语拼接成短语和句子改善了识别和模仿自然语言处理。 该系统使用与扬声器无关的连续语音来启动音频文件的播放。 该系统采用高速上下文切换来修改活动词汇，并应用高速上下文切换来修改或激活音频WAV语音响应文件。 系统使用对话历史来激活所选择的上下文，Baukus-Naur Form（BNF）语法和WAV文件，并提供短语或句子长对话提示，以提高准确性。 该系统还提供音频提示以提高精度，并提供语音激活的按钮以在菜单之间导航。