公开(公告)号：US20110294734A1

公开(公告)日：2011-12-01

申请号：US13147145

申请日：2010-02-04

申请人： Juan Manuel Irache Garreta ,  Fernando Martínez Galán

发明人： Juan Manuel Irache Garreta ,  Fernando Martínez Galán

IPC分类号： A61K47/48 ,  A61P9/00 ,  A61P25/00 ,  A61P9/10 ,  A61P29/00 ,  A61P21/00 ,  C07K17/10 ,  A61P9/12

CPC分类号： B82Y5/00 ,  A61K9/107 ,  A61K47/40 ,  A61K47/6951

摘要： The present invention relates to a complex comprising a TGF-β1 inhibitor peptide and a cyclodextrin or a derivative thereof. A TGF-β1 inhibitor peptide emulsion comprising cetyl PEG/PPG-10/1 dimethicone is also provided. Processes for the preparation of said complex and said TGF-β1 inhibitor peptide emulsion are also described, as well as its use for the manufacture of a medicament for the treatment of a disease or condition mediated by a TGF-β1.

摘要翻译： 本发明涉及包含TGF-β1抑制剂肽和环糊精或其衍生物的复合物。 还提供了包含十六烷基PEG / PPG-10/1聚二甲基硅氧烷的TGF-β1抑制剂肽乳液。 还描述了制备所述复合物和所述TGF-β1抑制剂肽乳液的方法，以及其用于制备用于治疗由TGF-β1介导的疾病或病症的药物的用途。