公开(公告)号：US09114111B2

公开(公告)日：2015-08-25

申请号：US13347513

申请日：2012-01-10

申请人： Julie Himes ,  Dennis Giesing ,  Cheryl Larrivee-Elkins ,  Michael J. Cima ,  Purnanand Sarma ,  Paul Goldenheim

发明人： Julie Himes ,  Dennis Giesing ,  Cheryl Larrivee-Elkins ,  Michael J. Cima ,  Purnanand Sarma ,  Paul Goldenheim

IPC分类号： A61M31/00 ,  A61K31/167 ,  A61K9/00

CPC分类号： A61K31/167 ,  A61K9/0034 ,  A61M25/00 ,  A61M31/002

摘要： Method are provided for treating a patient having bladder pain and/or irritative voiding symptoms. The method includes administering to the patient's bladder lidocaine or another anesthetic agent continuously over a treatment period of 24 hours or more in an amount effective to achieve a therapeutic effect which is sustained beyond the end of the treatment period.

摘要翻译： 提供了治疗患有膀胱疼痛和/或刺激性排尿症状的患者的方法。 该方法包括在24小时以上的治疗期间连续施用患者膀胱利多卡因或其他麻醉剂，其用量有效地达到治疗期结束以后持续的治疗效果。

公开(公告)号：US08690840B2

公开(公告)日：2014-04-08

申请号：US13267560

申请日：2011-10-06

申请人： Heejin Lee ,  Michael J. Cima ,  Cheryl Larrivee-Elkins ,  Dennis Giesing ,  Jessica K. Anderson ,  Sarma Duddu

发明人： Heejin Lee ,  Michael J. Cima ,  Cheryl Larrivee-Elkins ,  Dennis Giesing ,  Jessica K. Anderson ,  Sarma Duddu

IPC分类号： A61M31/00

CPC分类号： A61M31/002 ,  A61K9/0034 ,  A61K9/0039 ,  A61L29/148 ,  A61L29/16 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/00

摘要： Implantable medical devices and treatment methods are provided, particularly for use in the bladder. The device is configured for retention in the bladder for at least a portion of the drug delivery period and includes at least one biodegradable component such that following a biodegradation at a selected time, the retention function is lost and the device or portions thereof are resorbed and/or excreted. The method may include deploying into the bladder of a patient a device having a device structure housing a drug formulation comprising at a drug; releasing drug from the device structure into the bladder; and then, changing the composition of urine in the bladder, e.g., by altering the pH, to trigger degradation of at least part of the device structure to enable the device structure or parts thereof to be excreted from the bladder.

摘要翻译： 提供了可植入的医疗装置和治疗方法，特别用于膀胱。 该装置构造成在膀胱中保留药物递送期的至少一部分，并且包括至少一种可生物降解的组分，使得在选定时间内经过生物降解后，保留功能丧失并且其装置或部分被吸收， /或排泄。 该方法可以包括向患者的膀胱中部署具有容纳包含药物的药物制剂的装置结构的装置; 将药物从装置结构释放到膀胱中; 然后，例如通过改变pH来改变膀胱中尿液的组成，以触发装置结构的至少一部分的降解，使装置结构或其部分能够从膀胱排出。