公开(公告)号：US20100330103A1

公开(公告)日：2010-12-30

申请号：US12782335

申请日：2010-05-18

申请人： Julie RINKENBERGER ,  Ian FOLTZ ,  Avril ALFRED ,  Simon Thomas BARRY ,  Vahe BEDIAN

发明人： Julie RINKENBERGER ,  Ian FOLTZ ,  Avril ALFRED ,  Simon Thomas BARRY ,  Vahe BEDIAN

IPC分类号： A61K39/395 ,  C07K16/28 ,  A61P35/00 ,  A61P29/00

CPC分类号： C07K16/2839 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92 ,  C12N5/0686 ,  C12N2501/998

摘要： Targeted binding agents, such antibodies directed to the antigen αVβ6 and uses of such agents are described. In particular, fully human monoclonal antibodies directed to the antigen αVβ6 are disclosed. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3 are disclosed. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also disclosed.

摘要翻译： 描述了靶向结合剂，针对抗原αV和bgr的这种抗体以及这些药剂的用途。 特别地，公开了针对抗原αV和bgr的完全人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 被披露。 还公开了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。