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公开(公告)号:US09062118B2
公开(公告)日:2015-06-23
申请号:US12301827
申请日:2007-06-06
申请人: Julita S. Imperial , Baldomero M. Olivera , Paul F. Alewood , Heinz Terlau , David J. Craik , Estuardo Lopez-Vera , Pradip K. Bandyopadhyay
发明人: Julita S. Imperial , Baldomero M. Olivera , Paul F. Alewood , Heinz Terlau , David J. Craik , Estuardo Lopez-Vera , Pradip K. Bandyopadhyay
IPC分类号: A61K38/00 , C07K14/435
CPC分类号: C07K14/43504 , A61K38/00
摘要: The invention relates to relatively short peptides (termed J-Superfamily conotoxin peptides, J-conotoxins or J-conotoxin peptides herein), about 25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds. The J-conotoxins are useful for treating disorders involving voltage gated ion channels and/or receptors.
摘要翻译: 本发明涉及长度约25个残基的相对较短的肽(称为J-超家族荚果毒素肽,J-芋螺毒素或J-芋螺毒素肽),其在锥形蜗牛的毒液中天然可用量很少,或类似于 天然存在的肽,并且其优选包括两个二硫键。 J-芋螺毒素可用于治疗涉及电压门控离子通道和/或受体的疾病。
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公开(公告)号:US20110064668A1
公开(公告)日:2011-03-17
申请号:US12301827
申请日:2007-06-06
申请人: Julita S. Imperial , Baldomero M. Olivera , Paul F. Alewood , Heinz Terlau , David J. Craik , Estuardo Lopez-Vera , Pradip K. Bandyopadhyay
发明人: Julita S. Imperial , Baldomero M. Olivera , Paul F. Alewood , Heinz Terlau , David J. Craik , Estuardo Lopez-Vera , Pradip K. Bandyopadhyay
IPC分类号: A61K49/00 , C07K14/435 , C07H21/04 , A61K38/17 , A61P25/00
CPC分类号: C07K14/43504 , A61K38/00
摘要: The invention relates to relatively short peptides (termed J-Superfamily conotoxin peptides, J-conotoxins or J-conotoxin peptides herein), about 25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds. The J-conotoxins are useful for treating disorders involving voltage gated ion channels and/or receptors.
摘要翻译: 本发明涉及长度约25个残基的相对较短的肽(称为J-超家族荚果毒素肽,J-芋螺毒素或J-芋螺毒素肽),其在锥形蜗牛的毒液中天然可用量很少,或类似于 天然存在的肽,并且其优选包括两个二硫键。 J-芋螺毒素可用于治疗涉及电压门控离子通道和/或受体的疾病。
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