公开(公告)号：US5175313A

公开(公告)日：1992-12-29

申请号：US695323

申请日：1991-05-03

申请人： Junichi Imuta ,  Aiichiro Ori ,  Noriaki Kihara

发明人： Junichi Imuta ,  Aiichiro Ori ,  Noriaki Kihara

IPC分类号： C07D307/33

CPC分类号： C07D307/33

摘要： The present invention provides a process for preparing dihydrofuranone derivative of the formula (I): ##STR1## wherein R.sup.1 and R.sup.3 are individually lower alkyl, and R.sup.2 is hydrogen or lower alkyl, by reacting a dihydrofuranone derivative of the formula(I): ##STR2## wherein R.sup.1 is as defined above, with a malonic acid derivative of the formula (II): ##STR3## wherein R.sup.2 and R.sup.3 are as defined above, in the presence of an alkalimetal alkoxide and/or an alkalimetal hydroxide.

公开(公告)号：US5182198A

公开(公告)日：1993-01-26

申请号：US614132

申请日：1990-11-16

申请人： Shoichi Kise ,  Mikio Hayashida ,  Aiichiro Ori ,  Junzou Hiratsuka ,  Hideaki Yamada

发明人： Shoichi Kise ,  Mikio Hayashida ,  Aiichiro Ori ,  Junzou Hiratsuka ,  Hideaki Yamada

IPC分类号： C12P17/04 ,  C12P41/00 ,  C12R1/01 ,  C12R1/06 ,  C12R1/07 ,  C12R1/13 ,  C12R1/19 ,  C12R1/20 ,  C12R1/32 ,  C12R1/365 ,  C12R1/385 ,  C12R1/425 ,  C12R1/64 ,  C12R1/645 ,  C12R1/66 ,  C12R1/72 ,  C12R1/845

CPC分类号： C12P41/005 ,  C12P17/04 ,  Y10S435/822 ,  Y10S435/839 ,  Y10S435/84 ,  Y10S435/939

摘要： A process for preparing (+)-homopilopic acid and the salts thereof which comprises hydrolyzing a mixture of (+)-homopilopic acid ester of the general formula (I): ##STR1## wherein R.sub.1 denotes straight or branched C.sub.1 -C.sub.10 hydrocarbon, and (-)-homopilopic acid ester of the general formula (II): ##STR2## wherein R.sub.2 denotes straight or branched C.sub.1 -C.sub.10 hydrocarbon, in the presence of a microorganism belonging to the genus Arthrobacter, Aspergillus, Escherichia, Cunninghamella, Xanthomonas, Candida, Pseudomonas, Serratia, Cellulomonas, Nocardia, Bacillus, Brevibacterium, Flavobacterium, Mycobacterium, Rhizomucor, Rhodotorula or Rhodococcus, or a treated matter thereof.