公开(公告)号：US20230071910A1

公开(公告)日：2023-03-09

申请号：US17794245

申请日：2021-01-22

申请人： Juno Therapeutics, Inc.

发明人： Thalia FARAZI

IPC分类号： A61K35/17 ,  C07K14/725 ,  C07K16/28 ,  C12N5/0783

摘要： Provided herein are methods of administering a dose of T cells for treating subjects with indolent non-Hodgkin3 s lymphoma (NHL), and related methods, compositions, uses and articles of manufacture. The cells express a recombinant receptor such as a chimeric antigen receptor (CAR) for targeting an antigen of the lymphoma, such as CD19. In some embodiments, the methods are for treating grade 1-3 A follicular lymphoma (FL 1-3 A) or marginal zone lymphoma (MZL), including in heavily pretreated or poor-prognosis subjects, such as subjects that have relapsed after treatment with, or are refractory to treatment with, one or more prior therapies.