公开(公告)号：US20120114768A1

公开(公告)日：2012-05-10

申请号：US13383805

申请日：2010-07-12

申请人： Junya Fujimori ,  Hidekazu Baba ,  Toshinori Murata

发明人： Junya Fujimori ,  Hidekazu Baba ,  Toshinori Murata

IPC分类号： A61K33/00 ,  A61P27/02 ,  C01B21/20 ,  A61P27/06

CPC分类号： A61K33/00 ,  A61K31/21 ,  A61K33/26 ,  A61K2300/00

摘要： An angiogenesis regulating composition used to treat/prevent an angiogenic disease in a subject, that contains in an effective amount at least one of nitrate, nitrite, and a compound convertible into nitrate or nitrite after the compound is absorbed into the subject, and an angiogenesis regulation method administering to a subject a composition containing as an active ingredient at least one of nitrate. nitrite, and a compound convertible into nitrate or nitrite after the compound is absorbed into the subject, provide a composition effective in treating and preventing angiogenic diseases, that can medically control angiogenic diseases, and medically regulate angiogenesis in ophthalmologic diseases in particular, and allows treatment without inhibiting physiological neovascularization, with a limited side effect and significantly safely, and an angiogenesis regulation method using the same.

摘要翻译： 用于治疗/预防受试者血管生成疾病的血管发生调节组合物，其在所述化合物被吸收到受试者中之后含有有效量的硝酸盐，亚硝酸盐和可转化为硝酸盐或亚硝酸盐的化合物中的至少一种，以及血管发生 向受试者施用含有作为活性成分的至少一种硝酸盐的组合物的调节方法。 亚硝酸盐和化合物被吸收到受试者中后可转化为硝酸盐或亚硝酸盐的化合物，提供有效治疗和预防血管生成疾病的组合物，其可以医学上控制血管发生疾病，并且特别是在眼科疾病中医学调节血管发生，并且允许治疗 没有抑制生理新血管形成，副作用有限并且显着安全，以及使用其的血管生成调节方法。

公开(公告)号：US08974836B2

公开(公告)日：2015-03-10

申请号：US13897603

申请日：2013-05-20

申请人： Junya Fujimori ,  Hidekazu Baba ,  Toshinori Murata

发明人： Junya Fujimori ,  Hidekazu Baba ,  Toshinori Murata

IPC分类号： A61K33/00 ,  A61K31/21 ,  A61K33/26

CPC分类号： A61K33/00 ,  A61K31/21 ,  A61K33/26 ,  A61K2300/00

摘要： An angiogenesis regulating composition used to treat/prevent an angiogenic disease in a subject, that contains in an effective amount at least one of nitrate, nitrite, and a compound convertible into nitrate or nitrite after the compound is absorbed into the subject, and an angiogenesis regulation method administering to a subject a composition containing as an active ingredient at least one of nitrate, nitrite, and a compound convertible into nitrate or nitrite after the compound is absorbed into the subject, provide a composition effective in treating and preventing angiogenic diseases, that can medically control angiogenic diseases, and medically regulate angiogenesis in ophthalmologic diseases in particular, and allows treatment without inhibiting physiological neovascularization, with a limited side effect and significantly safely, and an angiogenesis regulation method using the same.

摘要翻译： 用于治疗/预防受试者血管生成疾病的血管发生调节组合物，其在所述化合物被吸收到受试者中之后含有有效量的硝酸盐，亚硝酸盐和可转化为硝酸盐或亚硝酸盐的化合物中的至少一种，以及血管发生 向受试者施用在化合物被吸收到受试者中后，向受试者施用含有硝酸盐，亚硝酸盐和可转化成硝酸盐或亚硝酸盐的化合物中的至少一种作为活性成分的组合物，提供有效治疗和预防血管生成疾病的组合物， 可以医学上控制血管生成疾病，特别是医学上调节眼科疾病的血管生成，并且允许治疗而不抑制生理新血管形成，副作用有限并且显着安全，以及使用其的血管生成调节方法。