公开(公告)号：US20220153727A1

公开(公告)日：2022-05-19

申请号：US17442306

申请日：2020-03-12

Applicant: KANEKA CORPORATION

Inventor： Takahiko MURATA ,  Shohei YAMAMOTO ,  Akira NISHIYAMA

IPC: C07D403/12

Abstract: The purpose of the present invention is to provide a method for producing a pyrrole-imidazole (poly)amide compound with the rapidly improved conversion rates, high yield and high reproducibility in the reaction forming an amide bond between a carboxy group binding to a pyrrole and an amino group binding to an imidazole. A method for producing a pyrrole-imidazole (poly)amide by reacting an aminoimidazole carboxylic acid derivative with a pyrrolecarboxylic acid derivative in the presence of a heterocyclic aromatic compound as a solvent.

公开(公告)号：US20210380632A1

公开(公告)日：2021-12-09

申请号：US16981868

申请日：2019-01-08

Applicant: KANEKA CORPORATION

Inventor： Takahiko MURATA ,  Shohei YAMAMOTO ,  Akira NISHIYAMA

IPC: C07K1/02 ,  C07K1/06 ,  C07K14/605

Abstract: The objective of the present invention is to provide a method for efficiently producing a long-chain peptide which method is suitable even for an industrial large scale production. The method for producing a long-chain peptide according to the present invention is characterized in comprising a step to deprotect an N-terminal site protected with BOC of a raw material peptide fragment with using a sulfonic acid compound, a step to selectively deprotect a C-terminal site protected with ONBn of a raw material peptide, and a step to condensate the obtained peptide fragment having the deprotected N-terminal site and the obtained peptide fragment having the deprotected C-terminal site in a liquid phase condition.