公开(公告)号：US09861801B2

公开(公告)日：2018-01-09

申请号：US14762534

申请日：2014-02-28

Applicant: Kimberly-Clark Worldwide, Inc.

Inventor： Andrew Baker ,  Russell F. Ross ,  Luke Hagan

IPC: A61M5/00 ,  A61M37/00

CPC classification number: A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0038 ,  A61M2037/0061 ,  A61M2210/04

Abstract: A drug delivery device is disclosed that may include a skin penetrating assembly having a support defining an upper surface and a lower surface. The skin penetrating assembly may also include a plurality of skin penetrating members extending outwardly from the lower surface. Each skin penetrating member may define a channel for receiving a drug formulation. In addition, the device may include a reservoir positioned adjacent to the upper surface of the support for initially retaining the drug formulation. The reservoir may include a top surface and a bottom surface and may define a plurality of passages extending between the top and bottom surfaces. The passages may be configured such that the drug formulation is retained within the passages against gravity.

公开(公告)号：US20160106965A1

公开(公告)日：2016-04-21

申请号：US14787044

申请日：2014-05-20

Applicant: KIMBERLY-CLARK WORLDWIDE, INC.

Inventor： Andrew Baker ,  Russell F. Ross ,  Sridhar Ranganathan

IPC: A61M37/00

CPC classification number: A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0038

Abstract: In one aspect a drug delivery device may include a reservoir containing a liquid drug formulation and a microneedle assembly in fluid communication with the reservoir. The microneedle assembly may include a plurality of microneedles, with each microneedle defining an open channel for receiving a drug formulation. The open channel may have a normalized hydraulic radius ranging from about 0.1 to about 0.8. The open channel may also have a liquid-to-solid interfacial energy and a liquid-to-vapor interfacial energy when a fixed volume of the drug formulation is received therein. In addition, the drug formulation and a cross-sectional geometry of the open channel may be selected and configured such that the liquid-to-solid energy exceeds the liquid-to-vapor energy as the length of the fixed volume of drug formulation is increased within the open channel.

Abstract translation: 在一个方面，药物递送装置可以包括容纳液体药物制剂和与储存器流体连通的微针组件的储存器。 微针组件可以包括多个微针，每个微针限定用于接收药物制剂的开放通道。 开放通道可以具有约0.1至约0.8的归一化液压半径。 当容纳固定体积的药物制剂时，开放通道也可具有液体 - 固体的界面能量和液体至蒸汽的界面能量。 此外，可以选择和构造药物制剂和开放通道的横截面几何形状，使得当药物制剂的固定体积的长度增加时，液体 - 固体能量超过液体至蒸气能量 在开放的渠道内。

公开(公告)号：US20150360018A1

公开(公告)日：2015-12-17

申请号：US14762534

申请日：2014-02-28

Applicant: Kimberly-Clark Worldwide, Inc.

Inventor： Andrew Baker ,  Russell F. Ross ,  Luke Hagan

IPC: A61M37/00

CPC classification number: A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0038 ,  A61M2037/0061 ,  A61M2210/04

Abstract: A drug delivery device is disclosed that may include a skin penetrating assembly having a support defining an upper surface and a lower surface. The skin penetrating assembly may also include a plurality of skin penetrating members extending outwardly from the lower surface. Each skin penetrating member may define a channel for receiving a drug formulation. In addition, the device may include a reservoir positioned adjacent to the upper surface of the support for initially retaining the drug formulation. The reservoir may include a top surface and a bottom surface and may define a plurality of passages extending between the top and bottom surfaces. The passages may be configured such that the drug formulation is retained within the passages against gravity.

Abstract translation: 公开了一种药物递送装置，其可以包括具有限定上表面和下表面的支撑物的皮肤穿透组件。 皮肤穿透组件还可以包括从下表面向外延伸的多个皮肤穿透构件。 每个皮肤穿透构件可以限定用于接收药物制剂的通道。 此外，装置可以包括邻近支撑件的上表面定位的储存器，用于初始保持药物制剂。 储存器可以包括顶表面和底表面，并且可以限定在顶表面和底表面之间延伸的多个通道。 通道可以被配置成使药物制剂保持在通道内以防止重力。

公开(公告)号：US20150174386A1

公开(公告)日：2015-06-25

申请号：US14134832

申请日：2013-12-19

Applicant: Kimberly-Clark Worldwide, Inc.

Inventor： Russell Frederick Ross ,  Andrew Baker

IPC: A61M37/00

CPC classification number: A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0038

Abstract: The present invention includes a microneedle assembly having a support that includes a first surface and a second surface, the second surface further including a slanted surface. A plurality of microneedles are provided which project outwardly from the second surface of the support. A pathway through the microneedle assembly is formed and includes an aperture extending between the first surface of the support and the second surface of the support, a channel disposed on the exterior surface of at least one microneedle, the channel having a surface, the channel being in alignment with at least a portion of the aperture to form a junction through which fluids may pass.

Abstract translation: 本发明包括具有包括第一表面和第二表面的支撑件的微针组件，所述第二表面还包括倾斜表面。 提供了多个微针，其从支撑件的第二表面向外突出。 形成通过微针组件的路径，并且包括在支撑件的第一表面和支撑件的第二表面之间延伸的孔，设置在至少一个微针的外表面上的通道，通道具有表面，通道为 与孔的至少一部分对准以形成流体可以通过的连接点。

公开(公告)号：US09795775B2

公开(公告)日：2017-10-24

申请号：US14787044

申请日：2014-05-20

Applicant: Kimberly-Clark Worldwide, Inc.

Inventor： Andrew Baker ,  Russell F. Ross ,  Sridhar Ranganathan

IPC: A61M5/00 ,  A61M37/00

CPC classification number: A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0038

Abstract: In one aspect a drug delivery device may include a reservoir containing a liquid drug formulation and a microneedle assembly in fluid communication with the reservoir. The microneedle assembly may include a plurality of microneedles, with each microneedle defining an open channel for receiving a drug formulation. The open channel may have a normalized hydraulic radius ranging from about 0.1 to about 0.8. The open channel may also have a liquid-to-solid interfacial energy and a liquid-to-vapor interfacial energy when a fixed volume of the drug formulation is received therein. In addition, the drug formulation and a cross-sectional geometry of the open channel may be selected and configured such that the liquid-to-solid energy exceeds the liquid-to-vapor energy as the length of the fixed volume of drug formulation is increased within the open channel.