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公开(公告)号：US20180297934A1
公开(公告)日：2018-10-18
申请号：US15823448
申请日：2017-11-27
IPC分类号： C07C225/14 , C07C49/743 , C07C49/707 , C07C69/612 , C07C69/28 , A61K31/122 , C07C69/78 , C07C69/96 , C07C59/90 , A61K31/135 , C07C251/42
CPC分类号： C07C225/14 , A61K31/122 , A61K31/135 , C07C49/707 , C07C49/743 , C07C59/90 , C07C69/02 , C07C69/22 , C07C69/28 , C07C69/612 , C07C69/614 , C07C69/78 , C07C69/96 , C07C251/42 , C07C2601/08 , C07C2601/10
摘要： The present application provides novel tetrahydro-isohumulone (THIAA) derivatives and substantially enantiomerically pure compositions and pharmaceutical formulations thereof. The application further provides methods of using the disclosed compounds and compositions to activate PPARγ, inhibit inflammation, and treat conditions associated with inflammation and conditions responsive to PPARγ modulation such as diabetes.
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公开(公告)号：US20150119461A1
公开(公告)日：2015-04-30
申请号：US14593164
申请日：2015-01-09
IPC分类号： C07C225/14 , C07C69/02 , C07C59/90 , C07C69/78 , C07C69/614 , C07C69/22 , C07C69/96
CPC分类号： C07C225/14 , A61K31/122 , A61K31/135 , C07C49/707 , C07C49/743 , C07C59/90 , C07C69/02 , C07C69/22 , C07C69/28 , C07C69/612 , C07C69/614 , C07C69/78 , C07C69/96 , C07C251/42 , C07C2601/08 , C07C2601/10
摘要： The present application provides novel tetrahydro-isohumulone (THIAA) derivatives and substantially enantiomerically pure compositions and pharmaceutical formulations thereof. The application further provides methods of using the disclosed compounds and compositions to activate PPARγ, inhibit inflammation, and treat conditions associated with inflammation and conditions responsive to PPARγ modulation such as diabetes.
摘要翻译： 本申请提供新的四氢异葎草酮（THIAA）衍生物和基本上对映体纯的组合物及其药物制剂。 本申请还提供了使用所公开的化合物和组合物来激活PPARγ，抑制炎症和治疗与炎症反应的病症和对PPARγ调节如糖尿病有反应的病症的方法。
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