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    T-TYPE CALCIUM CHANNEL INHIBITOR
    1.
    发明申请
    T-TYPE CALCIUM CHANNEL INHIBITOR 审中-公开

    公开(公告)号：US20200308132A1

    公开(公告)日：2020-10-01

    申请号：US16650746

    申请日：2018-09-21

    申请人： KINKI UNIVERSITY ,  NATIONAL UNIVERSITY CORPORATION UNIVERSITY OF TOYAMA ,  FUSO PHARMACEUTICAL INDUSTRIES, LTD.

    发明人： Atsufumi KAWABATA ,  Fumiko SEKIGUCHI ,  Maho TSUBOTA ,  Naoki TOYOOKA ,  Hiroyuki NISHIKAWA

    IPC分类号： C07D311/32 ,  A61P23/00

    摘要： A new analgesic has been developed for T-type calcium channels as therapeutic targets.The present invention provides a T-type calcium channel inhibitor which is a compound represented by formula (1): wherein each of R1 and R2 independently represents —H or —OH; R3 represents —OH; R4 represents —OH or —H; R5 represents a straight or branched alkyl or cycloalkyl-alkyl group having one to ten carbon atoms or a straight or branched alkenyl or cycloalkyl-alkenyl group having two to ten carbon atoms, or a pharmaceutically acceptable salt or solvate thereof. The present invention also provides this T-type calcium channel inhibitor, a medicament containing the T-type calcium channel inhibitor, and a therapeutic or prophylactic agent for a disease having an effective T-type calcium channel inhibitory action.

    T-TYPE CALCIUM CHANNEL INHIBITOR
    3.
    发明申请
    T-TYPE CALCIUM CHANNEL INHIBITOR 审中-公开

    公开(公告)号：US20180065947A1

    公开(公告)日：2018-03-08

    申请号：US15807064

    申请日：2017-11-08

    申请人： KINKI UNIVERSITY ,  FUSO PHARMACEUTICAL INDUSTRIES, LTD.

    发明人： Atsufumi KAWABATA ,  Hideaki MATSUDA ,  Fumiko SEKIGUCHI ,  Kazuya MURATA ,  Hiroyuki NISHIKAWA

    IPC分类号： C07D311/32 ,  A61K31/352

    CPC分类号： C07D311/32 ,  A61K31/352

    摘要： The present invention provides a T-type calcium channel inhibitor which is a compound represented by formula (1), a pharmaceutically acceptable salt of this compound or a solvate of this compound. The present invention also provides: this T-type calcium channel inhibitor; a pharmaceutical product containing this T-type calcium channel inhibitor; and a therapeutic agent or prophylactic agent for diseases, the effective action of which is a T-type calcium channel inhibitory action. (In formula (1), each of R1 and R2 independently represents H, —OH or —OR11 wherein R11 represents a C1-3 alkyl group; each of R3 and R4 independently represents H, —OH or —OR12, wherein R12 represents a C1-3 alkyl group; and each of R5 and R6 independently represents H, a halogen atom, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a phenyl group (which may be substituted by a C1-6 alkoxy group or a halogen atom), a —C1-3 alkyl-phenyl group (which may be substituted by a C1-6 alkyloxy group or a halogen atom) or a C10-50 prenyl group.)

    T-TYPE CALCIUM CHANNEL INHIBITOR
    4.
    发明申请
    T-TYPE CALCIUM CHANNEL INHIBITOR 审中-公开
    T型钙通道抑制剂

    公开(公告)号：US20160096815A1

    公开(公告)日：2016-04-07

    申请号：US14892392

    申请日：2014-05-16

    申请人： KINKI UNIVERSITY ,  FUSO PHARMACEUTICAL INDUSTRIES, LTD.

    发明人： Atsufumi KAWABATA ,  Hideaki MATSUDA ,  Fumiko SEKIGUCHI ,  Kazuya MURATA ,  Hiroyuki NISHIKAWA

    IPC分类号： C07D311/32

    CPC分类号： C07D311/32 ,  A61K31/352

    摘要： The present invention provides a T-type calcium channel inhibitor which is a compound represented by formula (1), a pharmaceutically acceptable salt of this compound or a solvate of this compound. The present invention also provides: this T-type calcium channel inhibitor; a pharmaceutical product containing this T-type calcium channel inhibitor; and a therapeutic agent or prophylactic agent for diseases, the effective action of which is a T-type calcium channel inhibitory action. (In formula (1), each of R1 and R2 independently represents H, —OH or —OR11, wherein R11 represents a C1-3 alkyl group; each of R3 and R4 independently represents H, —OH or —OR12, wherein R12 represents a C1-3 alkyl group; and each of R5 and R6 independently represents H, a halogen atom, a C1-10 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a phenyl group (which may be substituted by a C1-6 alkoxy group or a halogen atom), a —C1-3 alkyl-phenyl group (which may be substituted by a C1-6 alkyloxy group or a halogen atom) or a C10-50 prenyl group.)

    摘要翻译： 本发明提供了由式（1）表示的化合物，该化合物的药学上可接受的盐或该化合物的溶剂化物的T型钙通道抑制剂。 本发明还提供：该T型钙通道抑制剂; 含有该T型钙通道抑制剂的药物; 以及用于疾病的治疗剂或预防剂，其有效作用是T型钙通道抑制作用。 （式（1）中，R 1和R 2各自独立地表示H，-OH或-OR 11，其中R 11表示C 1-3烷基; R 3和R 4各自独立地表示H，-OH或-OR 12，其中R 12表示 C 1-3烷基; R 5和R 6各自独立地表示H，卤素原子，C 1-10烷基，C 2-6烯基，C 2-6炔基，苯基（可以被取代 通过C 1-6烷氧基或卤素原子），-C 1-3烷基 - 苯基（其可以被C 1-6烷氧基或卤素原子取代）或C10-50异戊烯基）。