公开(公告)号：US20240360457A1

公开(公告)日：2024-10-31

申请号：US18765587

申请日：2024-07-08

申请人： KIST (Korea Institute of Science and Technology) ,  K2B Therapeutics, Inc.

发明人： HoWon J. Kim ,  In-San Kim ,  Jay S. Kim ,  Sun Hwa Kim ,  Ick Chan Kwon ,  Jong Won Lee ,  Yoo Soo Yang ,  Hong Yeol Yoon

IPC分类号： C12N15/113 ,  A61P35/00

CPC分类号： C12N15/1138 ,  A61P35/00 ,  C12N2310/11 ,  C12N2310/531

摘要： Therapeutic compounds for red blood cell-mediated delivery of an active pharmaceutical ingredient to a cancer cell are described. The therapeutic compounds are configured to bind CD47 on the surface of a red blood cell and to be subsequently transferred to CD47 on the surface of the cancer cell, the therapeutic compound ultimately being internalized by the cancer cell via endocytosis.

公开(公告)号：US20240150771A1

公开(公告)日：2024-05-09

申请号：US18407815

申请日：2024-01-09

申请人： KIST (Korea Institute of Science and Technology) ,  K2B Therapeutics, Inc.

发明人： HoWon J. Kim ,  In-San Kim ,  Jay S. Kim ,  Sun Hwa Kim ,  Ick Chan Kwon ,  Jong Won Lee ,  Yoo Soo Yang ,  Hong Yeol Yoon

IPC分类号： C12N15/113 ,  A61P35/00

CPC分类号： C12N15/1138 ,  A61P35/00 ,  C12N2310/11 ,  C12N2310/531

摘要： Therapeutic compounds for red blood cell-mediated delivery of an active pharmaceutical ingredient to a target cell are described. The therapeutic compounds are configured to bind CD47 on the surface of a red blood cell and to be subsequently transferred to CD47 on the surface of the target cell, the therapeutic compound ultimately being internalized by the target cell via endocytosis. The target cell may be a fibrotic cell.

公开(公告)号：US20240325550A1

公开(公告)日：2024-10-03

申请号：US18618258

申请日：2024-03-27

申请人： KIST (Korea Institute of Science and Technology) ,  K2B Therapeutics, Inc.

发明人： HoWon J. Kim ,  In-San Kim ,  Jay S. Kim ,  Sun Hwa Kim ,  Ick Chan Kwon ,  Jong Won Lee ,  Yoo Soo Yang ,  Hong Yeol Yoon

IPC分类号： A61K47/64 ,  A61P35/00 ,  C12N15/113

CPC分类号： A61K47/64 ,  A61P35/00 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/141

摘要： Therapeutic compounds for inhibiting and reducing the expression of cell surface proteins and methods for treating cancer, inflammation, and diabetes using the therapeutic compounds.

公开(公告)号：US12006502B2

公开(公告)日：2024-06-11

申请号：US18407815

申请日：2024-01-09

申请人： KIST (Korea Institute of Science and Technology) ,  K2B Therapeutics, Inc.

发明人： HoWon J. Kim ,  In-San Kim ,  Jay S. Kim ,  Sun Hwa Kim ,  Ick Chan Kwon ,  Jong Won Lee ,  Yoo Soo Yang ,  Hong Yeol Yoon

IPC分类号： C12N15/113 ,  A61P35/00 ,  C12Q1/68

CPC分类号： C12N15/1138 ,  A61P35/00 ,  C12N2310/11 ,  C12N2310/531

摘要： Therapeutic compounds for red blood cell-mediated delivery of an active pharmaceutical ingredient to a target cell are described. The therapeutic compounds are configured to bind CD47 on the surface of a red blood cell and to be subsequently transferred to CD47 on the surface of the target cell, the therapeutic compound ultimately being internalized by the target cell via endocytosis. The target cell may be a fibrotic cell.

公开(公告)号：US20240191237A1

公开(公告)日：2024-06-13

申请号：US18407780

申请日：2024-01-09

申请人： KIST (Korea Institute of Science and Technology) ,  K2B Therapeutics, Inc.

发明人： HoWon J. Kim ,  In-San Kim ,  Jay S. Kim ,  Sun Hwa Kim ,  Ick Chan Kwon ,  Jong Won Lee ,  Yoo Soo Yang ,  Hong Yeol Yoon

IPC分类号： C12N15/113 ,  A61P35/00

CPC分类号： C12N15/1138 ,  A61P35/00 ,  C12N2310/11 ,  C12N2310/531

摘要： Therapeutic compounds for red blood cell-mediated delivery of an active pharmaceutical ingredient to a target cell are described. The therapeutic compounds are configured to bind CD47 on the surface of a red blood cell and to be subsequently transferred to CD47 on the surface of the target cell, the therapeutic compound ultimately being internalized by the target cell via endocytosis. The target cell may be a cancer cell.

公开(公告)号：US20240043846A1

公开(公告)日：2024-02-08

申请号：US18057050

申请日：2022-11-18

申请人： KIST (Korea Institute of Science and Technology) ,  K2B Therapeutics, Inc.

发明人： HoWon J. Kim ,  In-San Kim ,  Jay S. Kim ,  Sun Hwa Kim ,  Ick Chan Kwon ,  Jong Won Lee ,  Yoo Soo Yang ,  Hong Yeol Yoon

IPC分类号： C12N15/113 ,  A61P35/00

CPC分类号： C12N15/1138 ,  A61P35/00 ,  C12N2310/11 ,  C12N2310/531

摘要： Therapeutic compounds for red blood cell-mediated delivery of an active pharmaceutical ingredient to a target cell are described. The therapeutic compounds are configured to bind CD47 on the surface of a red blood cell and to be subsequently transferred to CD47 on the surface of the target cell, the therapeutic compound ultimately being internalized by the target cell via endocytosis. The target cell may be a cancer cell, a virus-infected cell, or a fibrotic cell.