公开(公告)号：US20100151503A1

公开(公告)日：2010-06-17

申请号：US12480465

申请日：2009-06-08

申请人： KOJI NAKAMURA ,  HIROKO ANZAI ,  HIROYUKI YANAI ,  ATSUSHI MIYAJIMA

发明人： KOJI NAKAMURA ,  HIROKO ANZAI ,  HIROYUKI YANAI ,  ATSUSHI MIYAJIMA

IPC分类号： G01N33/574

CPC分类号： C07K16/28 ,  C07K16/303 ,  C07K2317/734 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57438 ,  G01N2333/9121

摘要： Disclosed are a method for detecting liver cancer capable of detecting liver cancer with high specificity and a diagnostic therefor, as well as a novel therapeutic drug for cancer having an excellent anticancer effect. The method for detecting liver cancer cells in a sample utilizes as an index the expression of dlk gene. The expression of dlk gene may be measured by immunoassay using an anti-dlk antibody or by measuring mRNA of dlk gene. The therapeutic drug for cancer comprises as an effective ingredient an antibody which undergoes antigen-antibody reaction with Dlk expressing on surfaces of cancer cells and which exerts anticancer action against the cancer cells.

摘要翻译： 公开了一种能够高特异性检测肝癌的肝癌检测方法及其诊断方法，以及具有优异抗癌作用的新型癌症治疗药物。 检测样品中肝癌细胞的方法用作dlk基因的表达指标。 dlk基因的表达可以通过使用抗dlk抗体的免疫测定或通过测定dlk基因的mRNA来测量。 用于癌症的治疗药物包含作为有效成分的抗体，其与在癌细胞表面上表达的D1K进行抗原抗体反应并对癌细胞发挥抗癌作用。