公开(公告)号：US20180074047A1

公开(公告)日：2018-03-15

申请号：US15710887

申请日：2017-09-21

申请人： KONINKLIJKE PHILIPS N.V.

发明人： MAARTEN MARINUS JOHANNES WILHELMUS VAN HERPEN ,  DERK JAN WILFRED KLUNDER ,  HENDRIK ROELOF STAPERT

IPC分类号： G01N33/53

CPC分类号： G01N33/5306 ,  C40B30/10 ,  G01N21/6428

摘要： The invention relates to detection the presence of a target molecule in a sample, wherein the sample is contacted with a substrate, the substrate subsequently being washed in a wash step. In particular, the invention relates to a method of detecting the presence of a target molecule in a sample, the method comprising: (a) contacting the sample (37) with a substrate having immobilized thereon probe molecules that specifically binds to the target molecule; (b) washing the substrate (38) in a wash step by a wash fluid in order to remove or dilute unbound target molecules; (c) detect the presence of resultant binding complexes (39) on the substrate to determine whether the target molecule is present in the sample—The wash fluid being substantially refractive index matched to the substrate.

公开(公告)号：US20210205025A1

公开(公告)日：2021-07-08

申请号：US17059811

申请日：2019-06-06

申请人： KONINKLIJKE PHILIPS N.V.

发明人： RAMON QUIDO ERKAMP ,  HENDRIK ROELOF STAPERT ,  GUNTHER LAMPARTER ,  AMEET KUMAR JAIN ,  ALVIN CHEN ,  SHYAM BHARAT ,  KUNAL VAIDYA ,  FRANCOIS GUY GERARD MARIE VIGNON

IPC分类号： A61B34/20 ,  A61B8/00 ,  A61B8/08

摘要： A controller (240/340) for simultaneously tracking multiple interventional medical devices includes a memory (242/342) that stores instructions and a processor (241/341) that executes the instructions. When executed by the processor (241/341), the instructions cause the controller to execute a process that includes receiving timing information from a first signal emitted from an ultrasound probe (252/352) and reflective of timing when the ultrasound probe (252/352) transmits ultrasound beams to generate ultrasound imagery. The process executed by the controller also includes forwarding the timing information to be available for use by a first acquisition electronic component (232/332). The first acquisition electronic component (232/332) also receives sensor information from a first passive ultrasound sensor (S1) on a first interventional medical device (212/312). The timing information is used to synchronize the sensor information from the first passive ultrasound sensor (S1) on the first interventional medical device (212/312) with sensor information from a second passive ultrasound sensor (S2) on a second interventional medical device (216/316).

公开(公告)号：US20210361359A1

公开(公告)日：2021-11-25

申请号：US15733902

申请日：2019-06-11

申请人： KONINKLIJKE PHILIPS N.V.

发明人： RAMON QUIDO ERKAMP ,  HENDRIK ROELOF STAPERT ,  GUNTHER LAMPARTER ,  AMEET KUMAR JAIN ,  ALVIN CHEN ,  SHYAM BHARAT ,  KUNAL VAIDYA ,  FRANCOIS GUY GERARD MARIE VIGNON

IPC分类号： A61B34/20

摘要： A controller for determining orientation of an interventional medical device includes a memory that stores instructions, and a processor that executes the instructions. When executed by the processor, the instructions cause the controller to execute a process that includes controlling emission, by an ultrasound probe, of multiple beams each at a different combination of time of emission and angle of emission relative to the ultrasound probe. The process also includes determining, based on receipt of a response to a subset of the multiple beams at a sensor at a location on the interventional medical device, the combination of time of emission and angle of emission relative to the ultrasound probe of one of the subset of the multiple beams. The process also includes determining orientation of the interventional medical device based on the time of emission and angle of emission relative to the ultrasound probe of the one the subset of the multiple beams.

公开(公告)号：US20230031014A1

公开(公告)日：2023-02-02

申请号：US17965238

申请日：2022-10-13

申请人： KONINKLIJKE PHILIPS N.V.

发明人： RAMON QUIDO ERKAMP ,  HENDRIK ROELOF STAPERT ,  GUNTHER LAMPARTER ,  AMEET KUMAR JAIN ,  ALVIN CHEN ,  SHYAM BHARAT ,  KUNAL VAIDYA ,  FRANCOIS GUY GERARD MARIE VIGNON

IPC分类号： A61B34/20 ,  A61B8/08 ,  A61B8/00

摘要： A controller (240/340) for simultaneously tracking multiple interventional medical devices includes a memory (242/342) that stores instructions and a processor (241/341) that executes the instructions. When executed by the processor (241/341), the instructions cause the controller to execute a process that includes receiving timing information from a first signal emitted from an ultrasound probe (252/352) and reflective of timing when the ultrasound probe (252/352) transmits ultrasound beams to generate ultrasound imagery. The process executed by the controller also includes forwarding the timing information to be available for use by a first acquisition electronic component (232/332). The first acquisition electronic component (232/332) also receives sensor information from a first passive ultrasound sensor (S1) on a first interventional medical device (212/312). The timing information is used to synchronize the sensor information from the first passive ultrasound sensor (S1) on the first interventional medical device (212/312) with sensor information from a second passive ultrasound sensor (S2) on a second interventional medical device (216/316).