公开(公告)号：US12202879B2

公开(公告)日：2025-01-21

申请号：US17255629

申请日：2019-06-27

Applicant: KOOKMIN UNIVERSITY INDUSTRY ACADEMY COOPERATION FOUNDATION

Inventor： Sang Taek Jung ,  Ji Yeon Ha

IPC: C07K14/705 ,  C12N15/10 ,  A61K38/00

Abstract: A PD-L1 mutant having improved binding affinity for PD-1 is disclosed. A method for preparing the PD-L1 variant and a method for screening the PD-L1 variant are also disclosed. The PD-L1 variant produced by substituting some amino acids in the sequence of wild-type PD-L1 with other optimal amino acids, achieving greatly improved affinity for PD-1. In addition, the possibility of immunogenicity can be reduced by the smallest possible number of the mutation sites.