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1.发明授权Micelle structure of nano preparation for diagnosis or treatment of cancer disease and preparation method thereof 有权用于诊断或治疗癌症疾病的纳米制剂的胶束结构及其制备方法公开(公告)号：US09393308B2
公开(公告)日：2016-07-19
申请号：US14315943
申请日：2014-06-26
Inventor： Chulhee Choi , Kyuha Chong , Jiho Park
IPC: A61K47/24 , A61K31/122 , A61K9/107
CPC classification number: A61K47/24 , A61K9/1075 , A61K31/122
Abstract: Disclosed herein are a nanopreparation having a micelle structure for diagnosis or treatment of cancer diseases, and a method of preparing the same, and more particularly, a nanopreparation having a micelle structure available for diagonosis or treatment of cancer diseases and a method for preparing the same, wherein the nanopreparation is prepared by encapsulating a photosensitizer by forming micelle with polymeric lipid DSPE-mPEG. The nanopreparation having the micelle structure according to the present invention has a size of 12 nm or less by encapsulating hypericin, which is a photosensitizer, by forming micelle with polymeric lipid DSPE-mPEG having a molecular weight of 1500 to 2500. Resultingly, the nanopreparation easily overcomes a blood-tumor barrier (BTB) and an interstitial fluid pressure and has light induced cytotoxicity efficiency that is about more than 2.5 times higher than that of the case where hypericin is used alone.
Abstract translation: 本文公开了具有用于诊断或治疗癌症疾病的胶束结构的纳米制剂及其制备方法，更具体地，涉及具有可用于治疗癌症疾病的胶束结构的纳米制剂及其制备方法 其中通过用聚合脂质DSPE-mPEG形成胶束来包封光敏剂来制备纳米制备。 具有根据本发明的胶束结构的纳米制备通过用分子量为1500至2500的聚合脂质DSPE-mPEG形成胶束，通过包封金丝桃素（其是光敏剂）具有12nm或更小的尺寸。因此，纳米制备 容易克服血液肿瘤屏障（BTB）和间质液压力，并且具有比单独使用金丝桃素的情况高2.5倍以上的光诱导细胞毒性效应。
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2.发明申请MICELLE STRUCTURE OF NANO PREPARATION FOR DIAGNOSIS OR TREATMENT OF CANCER DISEASE AND PREPARATION METHOD THEREOF 有权纳米制备用于诊断或治疗癌症疾病的微波结构及其制备方法公开(公告)号：US20150148428A1
公开(公告)日：2015-05-28
申请号：US14315943
申请日：2014-06-26
Inventor： Chulhee Choi , Kyuha Chong , Jiho Park
IPC: A61K47/24 , A61K9/107 , A61K31/122
CPC classification number: A61K47/24 , A61K9/1075 , A61K31/122
Abstract: Disclosed herein are a nanopreparation having a micelle structure for diagnosis or treatment of cancer diseases, and a method of preparing the same, and more particularly, a nanopreparation having a micelle structure available for diagonosis or treatment of cancer diseases and a method for preparing the same, wherein the nanopreparation is prepared by encapsulating a photosensitizer by forming micelle with polymeric lipid DSPE-mPEG. The nanopreparation having the micelle structure according to the present invention has a size of 12 nm or less by encapsulating hypericin, which is a photosensitizer, by forming micelle with polymeric lipid DSPE-mPEG having a molecular weight of 1500 to 2500. Resultingly, the nanopreparation easily overcomes a blood-tumor barrier (BTB) and an interstitial fluid pressure and has light induced cytotoxicity efficiency that is about more than 2.5 times higher than that of the case where hypericin is used alone.
Abstract translation: 本文公开了具有用于诊断或治疗癌症疾病的胶束结构的纳米制剂及其制备方法，更具体地，涉及具有可用于治疗癌症疾病的胶束结构的纳米制剂及其制备方法 其中通过用聚合脂质DSPE-mPEG形成胶束来包封光敏剂来制备纳米制备。 具有根据本发明的胶束结构的纳米制备通过用分子量为1500至2500的聚合脂质DSPE-mPEG形成胶束，通过包封金丝桃素（其是光敏剂）具有12nm或更小的尺寸。因此，纳米制备 容易克服血液肿瘤屏障（BTB）和间质液压力，并且具有比单独使用金丝桃素的情况高2.5倍以上的光诱导细胞毒性效应。
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