公开(公告)号：US20240033304A1

公开(公告)日：2024-02-01

申请号：US18258643

申请日：2021-12-28

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Heung Kyu Lee ,  Jaeho Kim

IPC: A61K35/74 ,  A61K39/395 ,  A61P35/00

CPC classification number: A61K35/74 ,  A61K39/3955 ,  A61P35/00 ,  A61K2035/11

Abstract: The composition of the present invention induces changes in the composition of gut microbiota, particularly changes in the composition of Desulfovibrionasaceae strains, in a high glucose diet environment, so it has no toxicity to the body and has excellent brain tumor inhibitory activity, and thus it can effectively prevent, improve or treat brain tumors. Furthermore, such changes in the composition of gut microbiota in a high glucose diet environment induces a synergistic effect with anticancer drugs, particularly immune checkpoint inhibitors, and thus it can ultimately contribute to improving the survival rate of brain tumor patients.