公开(公告)号：US20240247272A1

公开(公告)日：2024-07-25

申请号：US18444881

申请日：2024-02-19

申请人： KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

发明人： Dae Soo KIM ,  Jin Kuk KIM ,  Ye Won LEE ,  Eun Ji JUNG ,  Min Sung PARK ,  Sin Jeong LEE ,  Su Jin CHAE

IPC分类号： C12N15/113 ,  A61P25/08 ,  A61P25/14 ,  A61P25/22 ,  A61P25/24 ,  A61P25/26

CPC分类号： C12N15/1138 ,  A61P25/08 ,  A61P25/14 ,  A61P25/22 ,  A61P25/24 ,  A61P25/26 ,  C12N2310/11 ,  C12N2310/3125 ,  C12N2310/313 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3231 ,  C12N2310/341

摘要： The present invention provides antisense oligonucleotides for the treatment of various T-type calcium channel α1G subunit-related disorders, and more specifically, antisense oligonucleotides for inhibiting expression of the gene encoding Cav3.1, targeting SEQ ID NO: 1, for the treatment of various neuropsychiatric disorders, including Parkinson's disease, epilepsy, essential tremor, depression, anxiety disorders, and unconsciousness.